Evidence map›Paper›PMID 33962942›Full record

ArticleScience advances2021

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells.

Despoina Kerselidou, Bushra Saeed Dohai, David R Nelson, Sarah Daakour, Nicolas De Cock, Zahra Al Oula Hassoun, Dae-Kyum Kim, Julien Olivet, Diana C El Assal, Ashish Jaiswal and 23 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 11 institutions in 7 countries.

Despoina KerselidouLaboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.ORCID 0000-0001-6768-3684
Bushra Saeed DohaiDivision of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE.ORCID 0000-0001-8179-8883
David R NelsonCenter for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, Abu Dhabi, UAE.ORCID 0000-0001-8868-5734
Sarah DaakourCenter for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, Abu Dhabi, UAE.
Nicolas De CockTERRA Teaching and Research Centre, University of Liege, Liege, Belgium.ORCID 0000-0002-4009-8845
Zahra Al Oula HassounLaboratory of Gene expression and Cancer, GIGA Institute, University of Liege, Liege, Belgium.ORCID 0000-0001-6125-2867
Dae-Kyum KimThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Julien OlivetLaboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.ORCID 0000-0003-4115-5546
Diana C El AssalDivision of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE.ORCID 0000-0003-1124-5153
Ashish JaiswalCenter for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, Abu Dhabi, UAE.ORCID 0000-0002-6193-1824
Amnah AlzahmiCenter for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, Abu Dhabi, UAE.
Deeya SahaLaboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.ORCID 0000-0002-5792-8307
Charlotte PainPlant Cell Biology, Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.ORCID 0000-0003-0350-9921
Filip MatthijssensDepartment of Biomolecular Medicine and Center for Medical Genetics, Ghent University, Ghent, Belgium.ORCID 0000-0002-6499-4572
Pierre LemaitreGIGA-I3 Unit, GIGA Institute, University of Liege, Liege, Belgium.ORCID 0000-0003-0687-8685
Michael HerfsGIGA-Cancer Unit, GIGA Institute, University of Liege, Liege, Belgium.
Julien ChapuisLaboratory of Excellence Distalz, INSERM Unit 1167, Pasteur Institute of Lille, Lille, France.ORCID 0000-0002-5802-2857
Bart GhesquiereMetabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.ORCID 0000-0003-1547-1705
Didier Vertommende Duve Institute, Catholic University of Louvain, Brussels, Belgium.ORCID 0000-0001-7648-8282
Verena KriechbaumerPlant Cell Biology, Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.ORCID 0000-0003-3782-5834
Kèvin KnoopsMicroscopy CORE Lab, Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.ORCID 0000-0002-7539-1160
Carmen Lopez-IglesiasMicroscopy CORE Lab, Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
Marc van ZandvoortDepartment of Cell Biology, School for Cardiovascular Diseases (CARIM), School for Nutrition and Translational Research in Metabolism (NUTRIM), School for Mental health and Neuroscience (MHeNS), and School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, Netherlands.
Jean-Charles LambertLaboratory of Excellence Distalz, INSERM Unit 1167, Pasteur Institute of Lille, Lille, France.ORCID 0000-0003-0829-7817
Julien HansonGIGA-Molecular Pharmacology, University of Liege, Liege, Belgium.ORCID 0000-0001-7063-7590
Christophe DesmetGIGA-I3 Unit, GIGA Institute, University of Liege, Liege, Belgium.ORCID 0000-0002-5723-2449
Marc ThiryLaboratory of cell and tissue Biology, GIGA-Neurosciences, University of Liege, Liege, Belgium.ORCID 0000-0002-4944-584X
Kyle J LauersenBiological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.ORCID 0000-0002-5538-7201
Marc VidalCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-3391-5410
Pieter Van VlierbergheDepartment of Biomolecular Medicine and Center for Medical Genetics, Ghent University, Ghent, Belgium.ORCID 0000-0001-9063-7205
Franck DequiedtLaboratory of Gene expression and Cancer, GIGA Institute, University of Liege, Liege, Belgium. fdequiedt@uliege.be ksa3@nyu.edu jean-claude.twizere@uliege.be.ORCID 0000-0003-1234-7477
Kourosh Salehi-AshtianiDivision of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE. fdequiedt@uliege.be ksa3@nyu.edu jean-claude.twizere@uliege.be.ORCID 0000-0002-6521-5243
Jean-Claude TwizereLaboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium. fdequiedt@uliege.be ksa3@nyu.edu jean-claude.twizere@uliege.be.ORCID 0000-0002-8683-705X
University of Liège · BENew York University · USMaastricht University · NLGhent University Hospital · BEInserm · FROxford Brookes University · GBde Duve Institute · BEHarvard University · USKing Abdullah University of Science and Technology · SAMount Sinai Hospital · CAVIB-KU Leuven Center for Cancer Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endoplasmic reticulum (ER) is a central eukaryotic organelle with a tubular network made of hairpin proteins linked by hydrolysis of guanosine triphosphate nucleotides. Among posttranslational modifications initiated at the ER level, glycosylation is the most common reaction. However, our understanding of the impact of glycosylation on the ER structure remains unclear. Here, we show that exostosin-1 (EXT1) glycosyltransferase, an enzyme involved in

Indexed as

Endoplasmic ReticulumEndoplasmic Reticulum StressAnimalsGlycosylationMammalsMiceProtein Processing, Post-TranslationalProtein Transport

Identifiers

PMID33962942
PMCPMC8104865
OpenAlexW3158613871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.