Evidence map›Paper›PMID 33962878›Full record

ReviewTrends in parasitology2021

Grappling with the tick microbiome.

Sukanya Narasimhan, Andrea Swei, Selma Abouneameh, Utpal Pal, Joao H F Pedra, Erol Fikrig

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
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  4. bioRxiv : the preprint server for biology · 2026
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sukanya NarasimhanSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA. Electronic address: sukanya.narasimhan@yale.edu.
Andrea SweiDepartment of Biology, San Francisco State University, San Francisco, CA 94132, USA.
Selma AbouneamehSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA.
Utpal PalDepartment of Veterinary Medicine, University of Maryland School of Medicine, College Park, MD 20472, USA.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 20472, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA.

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
The role of tick gut microbiota in Borrelia burgdorferi transmission to miceR01AI126033 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, NARASIMHAN, SUKANYA · 2017 to 2020
$1.7M
NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI126033NIDDK NIH HHS P30 DK034989
6 · The paper itself

Abstract

Ixodes scapularis and Ixodes pacificus are the predominant vectors of multiple human pathogens, including Borrelia burgdorferi, one of the causative agents of Lyme disease in North America. Differences in the habitats and host preferences of these closely related tick species present an opportunity to examine key aspects of the tick microbiome. While advances in sequencing technologies have accelerated a descriptive understanding of the tick microbiome, molecular and mechanistic insights into the tick microbiome are only beginning to emerge. Progress is stymied by technical difficulties in manipulating the microbiome and by biological variables related to the life cycle of Ixodid ticks. This review highlights these challenges and examines avenues to understand the significance of the tick microbiome in tick biology.

Indexed as

MicrobiotaAnimalsBacteriaIxodesSequence Analysis, DNAIxodes pacificusIxodes scapularistick-borne pathogenstick ecologytick innate immunitytick microbiome

Identifiers

PMID33962878
PMCPMC8282638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.