ArticleVeterinary research2021
Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep.
Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of LY2109761 on TGF-β1/TGFβRI/Smad Pathway and Hepatic Fibrosis Cysts Formation in Rats Infected with Echinococcus granulosus: an In Vitro and In Vivo Study.Acta parasitologica · 2026Article
- Differential activation of hepatic stellate cells by Echinococcus multilocularis and Echinococcus granulosus protoscoleces.Parasitology research · 2026Article
- Calprotectin Expression in Adventitial Layer of Cattle and SheepInternational journal of molecular sciences · 2025Article
- γδ T cell distribution in the adventitial layer of non-fertile cystic echinococcosis cysts from cattle livers.Scientific reports · 2025Article
- Article
- Zoonotic threat of cystic echinococcosis in Tunisia: insights into livestock prevalence and identification of the G1 genotype.Frontiers in veterinary science · 2025Article
- HLA class II profile in patients with different stages of cystic echinococcosis according to the WHO ultrasound imaging classification.Parasitology research · 2024Article
- Weighted gene co-expression network analysis reveals immune evasion related genes inExperimental biology and medicine (Maywood, N.J.) · 2024Article
- Detection ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Transcriptome analysis of Echinococcus granulosus sensu stricto protoscoleces reveals differences in immune modulation gene expression between cysts found in cattle and sheep.Veterinary research · 2022Article
- Metabolomics Analysis of Splenic CD19Frontiers in veterinary science · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Cystic echinococcosis is a zoonotic disease caused by the metacestode of Echinococcus granulosus sensu lato. The disease is characterized by the development of cystic structures inside viscera of the intermediate host, mainly liver and lungs. These cysts are formed by three layers: germinal, laminated, and adventitial layer, the latter being the local host immune response. Metacestodes that develop protoscoleces, the infective stage to the definitive host, are termed fertile, whereas cysts that do not produce protoscoleces are termed non-fertile. Sheep usually harbor fertile cysts while cattle usually harbor non-fertile cysts. Adventitial layers with fibrotic resolution are associated to fertile cysts, whereas a granulomatous reaction is associated with non-fertile cysts. The aim of this study was to analyze cellular distribution in the adventitial layer of fertile and non-fertile E. granulosus sensu stricto cysts found in liver and lungs of cattle and sheep. A total of 418 cysts were analyzed, 203 from cattle (8 fertile and 195 non-fertile) and 215 from sheep (64 fertile and 151 non-fertile). Fertile cysts from cattle showed mixed patterns of response, with fibrotic resolution and presence of granulomatous response in direct contact with the laminated layer, while sheep fertile cysts always displayed fibrotic resolution next to the laminated layer. Cattle non-fertile cysts display a granulomatous reaction in direct contact with the laminated layer, whereas sheep non-fertile cysts display a granulomatous reaction, but in direct contact with the fibrotic resolution. This shows that cattle and sheep cystic echinococcosis cysts have distinct local immune response patterns, which are associated to metacestode fertility.
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