Evidence map›Paper›PMID 33962661›Full record

ArticleMolecular brain2021

Developmental up-regulation of NMDA receptors in the prefrontal cortex and hippocampus of mGlu5 receptor knock-out mice.

Tiziana Imbriglio, Remy Verhaeghe, Nico Antenucci, Stefania Maccari, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tiziana Imbriglio *IRCCS Neuromed, Pozzilli, IS, Italy.
Remy Verhaeghe *IRCCS Neuromed, Pozzilli, IS, Italy.
Nico AntenucciDepartment of Physiology and Pharmacology "V. Erspamer", University Sapienza of Rome, Piazzale Aldo Moro, 5, 00185, Rome, Italy.
Stefania MaccariDepartment of Physiology and Pharmacology "V. Erspamer", University Sapienza of Rome, Piazzale Aldo Moro, 5, 00185, Rome, Italy.
Giuseppe BattagliaIRCCS Neuromed, Pozzilli, IS, Italy.
Ferdinando NicolettiIRCCS Neuromed, Pozzilli, IS, Italy. ferdinandonicoletti@hotmail.com.ORCID 0000-0003-0917-443X
Milena CannellaIRCCS Neuromed, Pozzilli, IS, Italy.
Istituto Neurologico Mediterraneo · ITCentre National de la Recherche Scientifique · FRSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

mGlu5 metabotropic glutamate receptors are highly expressed and functional in the early postnatal life, and are known to positively modulate NMDA receptor function. Here, we examined the expression of NMDA receptor subunits and interneuron-related genes in the prefrontal cortex and hippocampus of mGlu5

Indexed as

Up-RegulationAnimalsAnimals, NewbornDizocilpine MaleateGene DeletionHippocampusInterneuronsMiceMice, KnockoutPrefrontal CortexProtein SubunitsReceptor, Metabotropic Glutamate 5Receptors, N-Methyl-D-AspartateDizocilpine MaleateProtein SubunitsReceptor, Metabotropic Glutamate 5Receptors, N-Methyl-D-AspartateHippocampus MK-801Interneuron related genesLocomotor activityNMDA receptor subunitsPrefrontal cortex

Identifiers

PMID33962661
PMCPMC8106212
OpenAlexW3159038227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.