Evidence map›Paper›PMID 33962650›Full record

ArticleMolecular brain2021

Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.

Boren Lin, Khaled Alganem, Sinead M O'Donovan, Zhen Jin, FarzanehSadat Naghavi, Olivia A Miller, Tyler C Ortyl, Ye Chun Ruan, Robert E McCullumsmith, Jianyang Du

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Acid-sensing ion channels as sensors of brain metabolic state.Pflugers Archiv : European journal of physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Boren LinDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA.
Khaled AlganemDepartment of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA.
Sinead M O'DonovanDepartment of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA.
Zhen JinDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA.
FarzanehSadat NaghaviDepartment of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA.
Olivia A MillerDepartment of Biological Sciences, The University of Toledo, 43606, Toledo, OH, USA.
Tyler C OrtylDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA.
Ye Chun RuanDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.
Robert E McCullumsmithDepartment of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA.
Jianyang DuDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA. jdu15@uthsc.edu.ORCID 0000-0002-4342-0975
University of Tennessee Health Science Center · USUniversity of Toledo Medical Center · USHong Kong Polytechnic University · HKUniversity of Toledo · US

Funding

Translational assessment of brain bioenergetic function in schizophreniaR01MH121102 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI MARANO, CHRISTOPHER, MCCULLUMSMITH, ROBERT E · 2020 to 2024
$3.7M
Cell-specific analysis of sub-kinomes in schizophreniaR01MH107487 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI MCCULLUMSMITH, ROBERT E, MELLER, JAREK · 2016 to 2020
$1.9M
CO2 inhalation enhances the lability of fear memoryR01MH113986 · NIMH · UNIVERSITY OF TOLEDO · PI DU, JIANYANG · 2018 to 2022
$1.8M
NIMH NIH HHS R01 MH107487NIMH NIH HHS R01 MH113986NIMH NIH HHS R01 MH121102
6 · The paper itself

Abstract

Reconsolidation has been considered a process in which a consolidated memory is turned into a labile stage. Within the reconsolidation window, the labile memory can be either erased or strengthened. Manipulating acid-sensing ion channels (ASICs) in the amygdala via carbon dioxide (CO

Indexed as

Ion Channel GatingMemory ConsolidationProteolysisAcid Sensing Ion ChannelsAdministration, InhalationAmygdalaAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Carbon DioxideExcitatory Postsynaptic PotentialsFemaleMaleMiceMice, Inbred C57BLModels, BiologicalProteasome Endopeptidase ComplexAcid Sensing Ion ChannelsCalcium-Calmodulin-Dependent Protein Kinase Type 2Carbon DioxideProteasome Endopeptidase ComplexReceptors, AMPAUbiquitinAcid‐sensing ion channelsAMPA receptorsAversive conditioningCarbon dioxideMemory retrievalProteasomeProtein degradationReconsolidationUbiquitination

Identifiers

PMID33962650
PMCPMC8106190
OpenAlexW3157645572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.