ReviewCardiovascular diabetology2021
Variability of risk factors and diabetes complications.
Review in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine learning prediction models for diabetic kidney disease: systematic review and meta-analysis.Endocrine · 2024Pooled it
- Effect of Intensive Lifestyle Intervention on Cardiovascular Risk Factors: Analysis From the Perspective of Long-Term Variability.Journal of the American Heart Association · 2024Trial
- Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial.Diabetes & metabolism journal · 2022Trial
- Association of environmental xylene exposure with diabetic kidney disease: a cross-sectional analysis and multi-omics evaluation of immune microenvironment mechanisms.Renal failure · 2026Article
- Global Landscape and Thematic Evolution of Selective GLP-1 Receptor Agonists and GLP-1-Based Multi-Receptor Agonists in Type 2 Diabetes Mellitus: A Bibliometric Analysis.Endocrinology, diabetes & metabolism · 2026Review
- Abnormal Glycaemic Fluctuations Associated With Early Microvascular Changes in the Retina and Choroid of Nondiabetic Adults.Diabetes, obesity & metabolism · 2026Article
- Effect of diabetes on the efficacy and safety ofJournal of ginseng research · 2026Article
- Identification of Biomarkers forCurrent issues in molecular biology · 2026Article
- Trace Elements in the Pancreas: From Physiological Homeostasis to the Pathogenesis of Diabetes, Pancreatitis, and Cancer-A Review.Life (Basel, Switzerland) · 2026Review
- The Relationship Between Poor Glycemic Control and Diaphragmatic Thickness in Adults with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Life (Basel, Switzerland) · 2026Article
- Computational and Memory Efficiency in Heartbeat Rate Detection: A Review of ECG and PPG Techniques.Sensors (Basel, Switzerland) · 2026Article
- Impact of Body Mass Index Variability on Kidney Disease Progression in a Large Type 1 Diabetes Cohort.Diabetes/metabolism research and reviews · 2026Article
- Photobiomodulation and Low-Level Laser Therapy as Complementary Strategies in Diabetes Treatment.International journal of molecular sciences · 2026Review
- Persistent glycemic deterioration after the COVID-19 pandemic: A large cohort analysis stratifying by care settings, specialties, and gender disparities in Chengdu, China.Preventive medicine reports · 2026Article
- Role play of regulatory T cells and resolvins in type 2 diabetes.Frontiers in immunology · 2026Review
- Association of the TyG-GGT index, a novel insulin resistance marker, with incident diabetes mellitus: a large-scale retrospective cohort study.Frontiers in endocrinology · 2026Article
- Diabetes Mellitus in Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Prevalence of Types and Risk Factors.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Association of a novel index, the total cholesterol-high-density lipoprotein-glucose index, with diabetes mellitus in Chinese adults: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Natural Product-Based Nanomicelles: Properties, Fabrication Strategies, and Therapeutic Applications in Diseases.International journal of nanomedicine · 2026Review
- Associated Factors of Pre-Anesthesia Blood Pressure Elevation in Elective Non-Cardiac Surgical Patients: A Case-Control Study Comparing Two Diagnostic Thresholds.Risk management and healthcare policy · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies suggest that, together with glucose variability, the variability of other risk factors, as blood pressure, plasma lipids, heart rate, body weight, and serum uric acid, might play a role in the development of diabetes complications. Moreover, the variability of each risk factor, when contemporarily present, may have additive effects. However, the question is whether variability is causal or a marker. Evidence shows that the quality of care and the attainment of the target impact on the variability of all risk factors. On the other hand, for some of them causality may be considered. Although specific studies are still lacking, it should be useful checking the variability of a risk factor, together with its magnitude out of the normal range, in clinical practice. This can lead to an improvement of the quality of care, which, in turn, could further hesitate in an improvement of risk factors variability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.