Evidence map›Paper›PMID 33962575›Full record

ArticleBMC cancer2021

Clinical and prognostic features of patients with detailed RAS/BRAF-mutant colorectal cancer in Japan.

Tatsuki Ikoma, Mototsugu Shimokawa, Masahito Kotaka, Toshihiko Matsumoto, Hiroki Nagai, Shogen Boku, Nobuhiro Shibata, Hisateru Yasui, Hironaga Satake

Open access · goldAbstract read
In one paragraph

Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Prognostic factors of non-metastatic right colon adenocarcinoma: A multicentre retrospective analysis from the ATCCR database.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Observational
  5. Article
  6. Article
  7. Article
  8. East meets West: The winning combination againstWorld journal of clinical oncology · 2025
    Article
  9. Article
  10. Article
  11. Reclassification ofTherapeutic advances in medical oncology · 2024
    Article
  12. Clinical research progress on BRAF V600E-mutant advanced colorectal cancer.Journal of cancer research and clinical oncology · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. International journal of general medicine · 2023
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tatsuki IkomaDepartment of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.ORCID https://orcid.org/0000-0003-3758-3425
Mototsugu ShimokawaDepartment of Biostatistics, Yamaguchi University Graduate School of Medicine, Ube, 755-0046, Japan.
Masahito KotakaDepartment of Gastrointestinal Cancer Center, Sano Hospital, Kobe, 655-0031, Japan.
Toshihiko MatsumotoDepartment of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.
Hiroki NagaiDepartment of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.
Shogen BokuCancer Treatment Center, Kansai Medical University Hospital, 2-3-1, Shinmachi, Hirakata, Osaka, 573-1191, Japan.
Nobuhiro ShibataCancer Treatment Center, Kansai Medical University Hospital, 2-3-1, Shinmachi, Hirakata, Osaka, 573-1191, Japan.
Hisateru YasuiDepartment of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan.
Hironaga SatakeCancer Treatment Center, Kansai Medical University Hospital, 2-3-1, Shinmachi, Hirakata, Osaka, 573-1191, Japan. takeh1977@gmail.com.
Kobe City Medical Center General Hospital · JPKansai Medical University · JPYamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRAS/BRAF

methodsA total of 152 chemotherapy-naïve patients with mCRC were included in this study between August 2018 and July 2019. Tumor samples were collected, and RAS/BRAF

resultsRAS/BRAF

conclusionsIn our multicenter study, the findings elucidated the clinical and prognostic features of patients with detailed RAS/BRAF

Indexed as

MutationAdolescentAdultAgedAged, 80 and overColorectal NeoplasmsFemaleGTP PhosphohydrolasesHumansMaleMembrane ProteinsMiddle AgedPrognosisProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Young AdultBRAF protein, humanGTP PhosphohydrolasesKRAS protein, humanMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Colorectal cancerKRAS Exon2KRAS non-Exon2NRAS

Identifiers

PMID33962575
PMCPMC8105976
OpenAlexW3138059369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.