ArticleAdvances in nutrition (Bethesda, Md.)2021
Perspective: Framework for Developing Recommended Intakes of Bioactive Dietary Substances.
Article in Advances in nutrition (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Flavan-3-ols and Cardiometabolic Health: First Ever Dietary Bioactive Guideline.Advances in nutrition (Bethesda, Md.) · 2022Guideline
- Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults.The American journal of clinical nutrition · 2025Trial
- Approach to personalizing the treatment of osteoporosis.The Journal of clinical endocrinology and metabolism · 2026Review
- Adhering to dietary guidelines does not yield flavanol intake levels associated with beneficial cardiovascular effects.Food & function · 2026Article
- A Framework for Developing Intake and Use Guidance for Dietary Supplement Bioactives.Advances in nutrition (Bethesda, Md.) · 2026Review
- Dietary Supplement Bioactives: When Rigorous Frameworks Meet Regulatory Uncertainty.Advances in nutrition (Bethesda, Md.) · 2026Article
- How Is U.S. Food-Insecurity Related to Dietary Quality? A Scoping Review to Inform Nutrition Security Across the Lifespan.Nutrients · 2026Article
- Effect of replacing commonly consumed fruit in the United States with berries in the USDA healthy Dietary Patterns: a modeling analysis.Annals of medicine · 2025Article
- Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review.Nutrients · 2025Article
- Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease.Annual review of nutrition · 2023Review
- Perspectives on the application of CONSORT guidelines to randomised controlled trials in nutrition.European journal of nutrition · 2023Article
- Potential roles of dietary zeaxanthin and lutein in macular health and function.Nutrition reviews · 2023Review
- Have safety and efficacy assessments of bioactives come of age?Molecular aspects of medicine · 2023Review
- Dietary Supplements Use among Serbian Undergraduate Students of Different Academic Fields.International journal of environmental research and public health · 2022Article
- Bioactives in the Food Supply: Effects on CVD Health.Current atherosclerosis reports · 2022Review
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- Designing, Conducting, and Documenting Human Nutrition Plant-Derived Intervention Trials.Frontiers in nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary bioactives are food substances that promote health but are not essential to prevent typical deficiency conditions. Examples include lutein and zeaxanthin, omega-3 fatty acids, and flavonoids. When quality evidence is available, quantified intake recommendations linking dietary bioactives with specific health benefits will enable health professionals to provide evidence-based information to consumers. Without evidence-based recommendations, consumers use information from available sources that often lack standards and rigor. This article describes a framework to develop guidance based on quality evidence fully vetted for efficacy and safety by qualified experts, and designed to communicate the amounts of specific dietary bioactive compounds with identified health benefits. The 4-step Framework described here can be adapted by credible health organizations to work within their guideline development process. Standards of practice used in clinical guidelines are adapted to quantify dietary bioactive intake recommendations from foods consumed by the general public, by taking into account that side effects and trade-offs are often needed for medical treatments but are not acceptable for dietary bioactives. In quantifying dietary bioactive recommendations, this Framework establishes 4 decision-making steps: 1) characterize the bioactive, determine amounts in specific food sources, and quantify intakes; 2) evaluate safety; 3) quantify the causal relation between the specific bioactive and accepted markers of health or normal function via systematic evidence reviews; and 4) translate the evidence into a quantified bioactive intake statement. This Framework provides a working model that can be updated as new approaches are advanced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.