Evidence map›Paper›PMID 33962015›Full record

ArticlePharmacological research2021

Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr

Nawid Madjroh, Paul A Davies, Joshua L Smalley, Uffe Kristiansen, Pella C Söderhielm, Anders A Jensen

Open access · greenAbstract read
In one paragraph

Article in Pharmacological research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Understanding paralogous epilepsy-associated GABAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.British journal of pharmacology · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nawid MadjrohDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark.
Paul A DaviesDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Joshua L SmalleyDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Uffe KristiansenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark.
Pella C SöderhielmDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark.
Anders A JensenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark. Electronic address: aaj@sund.ku.dk.
University of Copenhagen · DKTufts University · US

Funding

Novel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0M
Determining the effects of human KCC2 mutations on neuronal excitabilityR21NS111338 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2019 to 2020
$454k
Sensory Hypersensitivity in Fragile X Syndrome Due to Deficits in Tonic Inhibition Reversed by Neuroactive SteroidsR21NS111064 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2020 to 2021
$450k
NIMH NIH HHS R01 MH097446NINDS NIH HHS R01 NS108378NINDS NIH HHS R21 NS111064NINDS NIH HHS R21 NS111338
6 · The paper itself

Abstract

The signalling characteristics of the Zinc-Activated Channel (ZAC), a member of the Cys-loop receptor (CLR) superfamily, are presently poorly elucidated. The ZACN polymorphism c.454G>A encoding for the Thr

Indexed as

AnimalsEnzyme-Linked Immunosorbent AssayImmunoprecipitationIon ChannelsOocytesPolymorphism, Single NucleotideXenopus laevisZincIon ChannelsZincCys-loop receptorHigh-frequency variationPentameric ligand-gated ion channelSingle nucleotide polymorphism (SNP)Two-electrode voltage clamp electrophysiologyZinc-Activated Channel (ZAC)

Identifiers

PMID33962015
PMCPMC8248299
OpenAlexW3159944504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.