Evidence map›Paper›PMID 33961945›Full record

ReviewNeuroscience letters2021

Role of innate immunity in chemotherapy-induced peripheral neuropathy.

Megan L Uhelski, Yan Li, Miriam M Fonseca, E Alfonso Romero-Snadoval, Patrick M Dougherty

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Innate immunity in chemotherapy-induced peripheral neuropathy: recent advances.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
  6. Article
  7. Article
  8. A perspective: neuraxial therapeutics in pain management: now and future.Frontiers in pain research (Lausanne, Switzerland) · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Megan L UhelskiThe Department of Pain Medicine Research, The Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas M.D. Anderson Cancer Center, United States.
Yan LiThe Department of Pain Medicine Research, The Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas M.D. Anderson Cancer Center, United States.
Miriam M FonsecaThe Department of Anesthesiology, Wake Forest School of Medicine, United States.
E Alfonso Romero-SnadovalThe Department of Anesthesiology, Wake Forest School of Medicine, United States.
Patrick M DoughertyThe Department of Pain Medicine Research, The Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas M.D. Anderson Cancer Center, United States. Electronic address: pdougherty@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USWake Forest University · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Translation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7M
Anatomic, Physiologic and Transcriptomic Mechanisms of Neuropathic Pain in Human DRGR01NS111929 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DOUGHERTY, PATRICK M, PRICE, THEODORE J. · 2020 to 2024
$3.4M
The role of ENF loss, TLR4 and spinal plasticity in paclitaxel CIPNR01CA200263 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DOUGHERTY, PATRICK M · 2016 to 2020
$2.4M
Endoplasmic Reticulum Stress Responses in PainR01NS114653 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOADA, MARIO DANILO, ROMERO-SANDOVAL, E. ALFONSO · 2020 to 2024
$2.0M
IRE1a-XBP1 Signaling as a Driver of Chemotherapy-Induced Peripheral NeuropathyR21CA248106 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CUBILLOS-RUIZ, JUAN R, ROMERO-SANDOVAL, E. ALFONSO · 2020 to 2021
$420k
NCATS NIH HHS UL1 TR001420NCI NIH HHS R01 CA200263NCI NIH HHS R21 CA248106NINDS NIH HHS R01 NS065926NINDS NIH HHS R01 NS111929NINDS NIH HHS R01 NS114653
6 · The paper itself

Abstract

It has become increasingly clear that the innate immune system plays an essential role in the generation of many types of neuropathic pain including that which accompanies cancer treatment. In this article we review current findings of the role of the innate immune system in contributing to cancer treatment pain at the distal endings of peripheral nerve, in the nerve trunk, in the dorsal root ganglion and in the spinal dorsal horn.

Indexed as

AnimalsAntineoplastic AgentsGanglia, SpinalHumansImmunity, InnateNeuralgiaSpinal Cord Dorsal HornAntineoplastic AgentsBortezomibMacrophageOxaliplatinPaclitaxelTLR4

Identifiers

PMID33961945
PMCPMC8190706
OpenAlexW3158496680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.