ArticleMathematical biosciences2021
COVID-19 optimal vaccination policies: A modeling study on efficacy, natural and vaccine-induced immunity responses.
Article in Mathematical biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Predictive models for health outcomes due to SARS-CoV-2, including the effect of vaccination: a systematic review.Systematic reviews · 2024Pooled it
- Optimising pandemic response through vaccination strategies using neural networks.Scientific reports · 2026Article
- Optimizing vaccination strategies under uncertainty to prevent epidemics.Frontiers in public health · 2026Article
- Discussing the epidemiology of COVID-19 model with the effective numerical scheme.Scientific reports · 2025Article
- HPV transmission and optimal control of cervical cancer in China.Scientific reports · 2025Article
- Impact of COVID-19 vaccinations in India: a state-wise analysis.BMC public health · 2025Article
- Learning from the COVID-19 pandemic: A systematic review of mathematical vaccine prioritization models.Infectious Disease Modelling · 2024Review
- Article
- A vaccination-based COVID-19 model: Analysis and prediction using Hamiltonian Monte Carlo.Heliyon · 2024Article
- Novel multi-cluster workflow system to support real-time HPC-enabled epidemic science: Investigating the impact of vaccine acceptance on COVID-19 spread.Journal of parallel and distributed computing · 2024Article
- Valuation and comparison of the actual and optimal control strategy in an emerging infectious disease: Implication from a COVID-19 transmission model.Infectious Disease Modelling · 2024Article
- Learning from the COVID-19 pandemic: a systematic review of mathematical vaccine prioritization models.medRxiv : the preprint server for health sciences · 2024Article
- Analysis of the COVID-19 pandemic using a compartmental model with time-varying parameters fitted by a genetic algorithm.Expert systems with applications · 2023Article
- An integrated chance constraints approach for optimal vaccination strategies under uncertainty for COVID-19.Socio-economic planning sciences · 2023Article
- Impact of vaccination on the entire population and dose-response relation of COVID-19.Vacunas · 2023Article
- Study of optimal vaccination strategies for early COVID-19 pandemic using an age-structured mathematical model: A case study of the USA.Mathematical biosciences and engineering : MBE · 2023Article
- Modeling the Spread of COVID-19 with the Control of Mixed Vaccine Types during the Pandemic in Thailand.Tropical medicine and infectious disease · 2023Article
- Article
- Article
- COVID-19 vaccination challenges: A mini-review.Human vaccines & immunotherapeutics · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About a year into the pandemic, COVID-19 accumulates more than two million deaths worldwide. Despite non-pharmaceutical interventions such as social distance, mask-wearing, and restrictive lockdown, the daily confirmed cases remain growing. Vaccine developments from Pfizer, Moderna, and Gamaleya Institute reach more than 90% efficacy and sustain the vaccination campaigns in multiple countries. However, natural and vaccine-induced immunity responses remain poorly understood. There are great expectations, but the new SARS-CoV-2 variants demand to inquire if the vaccines will be highly protective or induce permanent immunity. Further, in the first quarter of 2021, vaccine supply is scarce. Consequently, some countries that are applying the Pfizer vaccine will delay its second required dose. Likewise, logistic supply, economic and political implications impose a set of grand challenges to develop vaccination policies. Therefore, health decision-makers require tools to evaluate hypothetical scenarios and evaluate admissible responses. Following some of the WHO-SAGE recommendations, we formulate an optimal control problem with mixed constraints to describe vaccination schedules. Our solution identifies vaccination policies that minimize the burden of COVID-19 quantified by the number of disability-adjusted years of life lost. These optimal policies ensure the vaccination coverage of a prescribed population fraction in a given time horizon and preserve hospitalization occupancy below a risk level. We explore "via simulation" plausible scenarios regarding efficacy, coverage, vaccine-induced, and natural immunity. Our simulations suggest that response regarding vaccine-induced immunity and reinfection periods would play a dominant role in mitigating COVID-19.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.