Evidence map›Paper›PMID 33961792›Full record

ArticleStem cell reports2021

Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer.

Xiaoming Ouyang, Yu Liu, Yang Zhou, Jing Guo, Tzu-Tang Wei, Chun Liu, Bomi Lee, Binbin Chen, Angela Zhang, Kerriann M Casey and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

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  16. An iPSC-derived exosome-pulsed dendritic cell vaccine boosts antitumor immunity in melanoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Xiaoming OuyangStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA.
Yu LiuStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA.
Yang ZhouStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA.
Jing GuoDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Tzu-Tang WeiStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA.
Chun LiuStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA.
Bomi LeeDepartment of Medicine, Division of Gastroenterology & Hepatology, Stanford University, Stanford, CA 94305, USA.
Binbin ChenDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Angela ZhangStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA.
Kerriann M CaseyDepartment of Comparative Medicine, Stanford University, Stanford, CA 94305, USA.
Lin WangStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA.
Nigel G KooremanDepartment of Surgery, Leiden University Medical Center, Leiden, ZA 2333, the Netherlands.
Aida HabtezionDepartment of Medicine, Division of Gastroenterology & Hepatology, Stanford University, Stanford, CA 94305, USA.
Edgar G EnglemanDepartment of Pathology, Stanford University, Stanford, CA 94305, USA. Electronic address: edgareng@stanford.edu.
Joseph C WuStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA. Electronic address: joewu@stanford.edu.
Stanford University · USCardiovascular Institute of the South · USLeiden University Medical Center · NL

Funding

Spatial-Genomic Integrative Multi-Species Analysis of Lymph Node MetastasisU54CA209971 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P, PLEVRITIS, SYLVIA KATINA · 2016 to 2021
$11.0M
T32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3M
Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCsR01HL141851 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$5.7M
Modeling Susceptibility to Chemotherapy-Induced Cardiotoxicity Using Human iPSCsR01HL123968 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS, WU, JOSEPH C. · 2014 to 2021
$4.8M
Targeting Dectin-2 on Tumor-associated Macrophages for the Treatment of CancerR01CA222969 · NCI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2018 to 2022
$2.1M
Assessment of Low-Dose Radiation Risk and Mechanisms of Individual RadiosensitivityR01HL132875 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2016 to 2019
$1.9M
CyTOFS10OD016318 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2013 to 2013
$600k
Using Deep Learning to Predict Induced Pluripotent Stem Cell-Derived Cardiomyocyte (iPSC-CM) Differentiation OutcomesF30HL156478 · NHLBI · STANFORD UNIVERSITY · PI ZHANG, ANGELA · 2021 to 2023
$118k
NCI NIH HHS R01 CA222969NCI NIH HHS U54 CA209971NHLBI NIH HHS F30 HL156478NHLBI NIH HHS R01 HL123968NHLBI NIH HHS R01 HL132875NHLBI NIH HHS R01 HL141851NHLBI NIH HHS T32 HL098049NIH HHS S10 OD016318
6 · The paper itself

Abstract

Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8

Indexed as

AnimalsAntineoplastic AgentsCancer VaccinesCarcinoma, Pancreatic DuctalCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalFemaleHumansImmunologic MemoryInduced Pluripotent Stem CellsMiceMice, Inbred C57BLPancreatic NeoplasmsT-Lymphocytopenia, Idiopathic CD4-PositiveTranscriptomeAntineoplastic AgentsCancer Vaccinescancer vaccineiPSCiPSC-based cancer vaccinepancreatic ductal adenocarcinomatumor-associated antigens

Identifiers

PMID33961792
PMCPMC8190592
OpenAlexW3157791705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.