Evidence map›Paper›PMID 33961755›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes.

Polly F M Robinson, Sara Fontanella, Sachin Ananth, Aldara Martin Alonso, James Cook, Daphne Kaya-de Vries, Luisa Polo Silveira, Lisa Gregory, Clare Lloyd, Louise Fleming and 3 more

Registry-linked trialOpen access · hybridAbstract readComparative Study
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06237660 (Development of Non-invasive Biomarkers to Direct Individualised Management of Preschool Wheeze), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06237660 recruitingnot on this mapstarted 2024, after this paper: background citation

Development of Non-invasive Biomarkers to Direct Individualised Management of Preschool Wheeze

TypeobservationalSponsorImperial College LondonRan2024 to 2026Enrolled150ConditionsWheezingArmsBronchoscopy, with bronchoalveolar lavage and endobronchial biopsy, Skin prick test, Finger prick blood test, Forced oscillation technique (FOT), Sputum induction
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
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  11. Article
  12. Risk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma.The journal of allergy and clinical immunology. In practice · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Association between nasopharyngeal airway lipidome signatures of infants with severe bronchiolitis and risk of recurrent wheeze: A prospective multicenter cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Article
  17. Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Polly F M RobinsonNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.ORCID 0000-0003-2463-3024
Sara FontanellaNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Sachin AnanthNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Aldara Martin AlonsoNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
James CookNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Daphne Kaya-de VriesNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Luisa Polo SilveiraNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Lisa GregoryNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Clare LloydNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Louise FlemingNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Andrew BushNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Adnan CustovicNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.ORCID 0000-0001-5218-7071
Sejal SaglaniNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Harefield Hospital · GBImperial College London · GB

Funding

Department of Health CDF-2014-07-019Medical Research Council MR/S025340/1Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Symptom AssessmentAsthmaChild, PreschoolFemaleGenetic VariationGenotypeHumansInfantMalePhenotypeRespiratory SoundsRisk FactorsSeverity of Illness Indexcluster analysisendotypesinfectioninflammationpediatric wheeze

Identifiers

PMID33961755
PMCPMC8491264
OpenAlexW3159497397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.