Evidence map›Paper›PMID 33961735›Full record

ArticleEMBO molecular medicine2021

Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.

Yi-Hao Chan, Siew-Wai Fong, Chek-Meng Poh, Guillaume Carissimo, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Yun Shan Goh, Jackwee Lim, Weili Xu, Rhonda Sin-Ling Chee and 16 more

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. ACS pharmacology & translational science · 2025
    Article
  6. Article
  7. Article
  8. Consequences of COVID-19 on Adipose Tissue Signatures.International journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yi-Hao ChanA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-0329-238X
Siew-Wai FongA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-5326-489X
Chek-Meng PohA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-0059-3937
Guillaume CarissimoA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-9703-9096
Nicholas Kim-Wah YeoA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-8294-1474
Siti Naqiah AmrunA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0001-6939-8123
Yun Shan GohA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.
Jackwee LimSingapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-4344-6822
Weili XuSingapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-6040-2883
Rhonda Sin-Ling CheeA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-2598-3288
Anthony Torres-RuestaA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-0447-3131
Cheryl Yi-Pin LeeA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-5265-0377
Matthew Zirui TayA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-1763-913X
Zi Wei ChangA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-7461-9098
Wen-Hsin LeeSingapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-0315-7495
Bei WangSingapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-3112-7341
Seow-Yen TanDepartment of Infectious Diseases, Changi General Hospital, Singapore City, Singapore.ORCID 0000-0001-7870-2879
Shirin KalimuddinDepartment of Infectious Diseases, Singapore General Hospital, Singapore City, Singapore.ORCID 0000-0001-9319-5908
Barnaby Edward YoungNational Centre for Infectious Diseases, Singapore City, Singapore.ORCID 0000-0003-1010-2230
Yee-Sin LeoNational Centre for Infectious Diseases, Singapore City, Singapore.ORCID 0000-0003-4978-5825
Cheng-I WangSingapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0001-9170-2996
Bernett LeeSingapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0002-2709-1972
Olaf RötzschkeSingapore Immunology Network, Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0001-8336-5248
David Chien LyeNational Centre for Infectious Diseases, Singapore City, Singapore.ORCID 0000-0003-0324-0205
Laurent ReniaA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-0349-1557
Lisa F P NgA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research, Singapore City, Singapore.ORCID 0000-0003-4071-5222

Funding

A*STAR|Biomedical Research Council (BMRC) H16/99/b0/011A*STAR|Biomedical Research Council (BMRC) H/20/04/g1/006A*STAR|Biomedical Research Council (BMRC) IAF 311006MOH|National Medical Research Council (NMRC) COVID190RF-060MOH|National Medical Research Council (NMRC) COVID19RF-001MOH|National Medical Research Council (NMRC) COVID19-RF007National Research Foundation Singapore (NRF) NRF2017_SISFP09
6 · The paper itself

Abstract

The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169

Indexed as

BiomarkersBrain-Derived Neurotrophic FactorCarrier StateCOVID-19CytokinesHumansMonocytesNeutrophilsSARS-CoV-2Th17 CellsTranscriptomeUp-RegulationVascular Endothelial Growth Factor DBiomarkersBrain-Derived Neurotrophic FactorCytokinesVascular Endothelial Growth Factor DasymptomaticCOVID-19disease toleranceSARS-CoV-2

Identifiers

PMID33961735
PMCPMC8185544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.