Evidence map›Paper›PMID 33961545›Full record

ReviewThe Science of the total environment2021

Association of COVID-19 transmission with high levels of ambient pollutants: Initiation and impact of the inflammatory response on cardiopulmonary disease.

Angela Lai, Megan L Chang, Ryan P O'Donnell, Changcheng Zhou, Jennifer A Sumner, Tzung K Hsiai

Open access · greenAbstract readReview
In one paragraph

Review in The Science of the total environment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Impact of air pollution on COVID-19 severity: a systematic review of underlying biological mechanisms.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Relationship between COVID-19 Cases and Environmental Contaminants in Quito, Ecuador.International journal of environmental research and public health · 2024
    Article
  6. Article
  7. Is Pollution the Primary Driver of Infectious Syndemics?Pathogens (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Role of Dentist: COVID19 and Mucormycosis.Journal of pharmacy & bioallied sciences · 2022
    Review
  12. Article
  13. Review
  14. Effect of Green Space Environment on Air Pollutants PM2.5, PM10, CO, OInternational journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Angela LaiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States of America.
Megan L ChangDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States of America.
Ryan P O'DonnellDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States of America.
Changcheng ZhouDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, United States of America.
Jennifer A SumnerDepartment of Psychology, College of Life Sciences, University of California, Los Angeles, United States of America.
Tzung K HsiaiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States of America; Department of Medicine, Greater Los Angeles VA Healthcare System, Los Angeles, CA, United States of America; Department of Bioengineering, Henry Samueli School of Engineering & Applied Science, University of California, Los Angeles, CA, United States of America. Electronic address: THsiai@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of California, Riverside · USVA Greater Los Angeles Healthcare System · US

Funding

Identifying Early Intervention Targets for Reducing Cardiovascular Risk in Posttraumatic StressR01HL139614 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMNER, JENNIFER A · 2018 to 2022
$3.9M
Linking Spatial Variations Shear Stress-Oxidative StressR01HL083015 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2006 to 2015
$3.9M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
Endocrine disruptor mediated activation of PXR causes dyslipidemia and atherosclerosisR01ES023470 · NIEHS · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2013 to 2022
$2.7M
Role of IKKβ in obesity and atherosclerosisR01HL131925 · NHLBI · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2016 to 2019
$1.5M
A novel mechanism for ART-associated dyslipidemia and atherosclerosisR01HL123358 · NHLBI · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2015 to 2018
$1.5M
iDISCOVER: Integrated Data Science Training in CardioVascular MedicineT32HL139450 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUI, ALEX, PING, PEIPEI · 2018 to 2022
$1.3M
Posttraumatic Stress and Cardiovascular Risk in Women: Tests of Biological MechanismsK01HL130650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMNER, JENNIFER A · 2016 to 2020
$815k
Exercise-Induced Shear Stress Modulates Metabolic Pathways for Vascular Repair and ProtectionI01BX004356 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI HSIAI, TZUNG K · 2019 to 2024
–
BLRD VA I01 BX004356NHLBI NIH HHS K01 HL130650NHLBI NIH HHS R01 HL083015NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL123358NHLBI NIH HHS R01 HL129727NHLBI NIH HHS R01 HL131925NHLBI NIH HHS R01 HL139614NHLBI NIH HHS T32 HL139450NIEHS NIH HHS R01 ES023470
6 · The paper itself

Abstract

Ambient air pollution contributes to 7 million premature deaths annually. Concurrently, the ongoing coronavirus disease 2019 (COVID-19) pandemic, complicated with S-protein mutations and other variants, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 2.5 million deaths globally. Chronic air pollution-mediated cardiopulmonary diseases have been associated with an increased incidence of hospitalization and mechanical ventilation following COVID-19 transmission. While the underlying mechanisms responsible for this association remain elusive, air pollutant-induced vascular oxidative stress and inflammatory responses have been implicated in amplifying COVID-19-mediated cytokine release and vascular thrombosis. In addition, prolonged exposure to certain types of particulate matter (PM

Indexed as

COVID-19Environmental PollutantsCommunicable Disease ControlHumansPandemicsSARS-CoV-2Environmental PollutantsAir pollutionCardiopulmonary effectsCOVID-19SARS-CoV-2

Identifiers

PMID33961545
PMCPMC7960028
OpenAlexW3137555263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.