ReviewJournal of medical microbiology2021
Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens.
Review in Journal of medical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- From Antibacterial to Antifungal: Structure, Safety, and Serum Albumin Binding of Zn(II)-Nalidixate Complexes with Phenanthroline and Bipyridine.Biological trace element research · 2026Article
- Inhibition and disruption of bacterial biofilms by a bipyridine-ruthenium complex: a broad-spectrum in vitro study.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Distinct sub-MIC kill kinetics of Cu and Ag inMicrobiology spectrum · 2026Article
- Exploring Zinc(II) Coordination Chemistry with Picolinate and Amino Alcohols: Toward New Antibacterial Agents.ACS omega · 2026Article
- Metal-antibiotic interactions: potentiometric and spectroscopic investigation of cloxacillin and dicloxacillin complexes in aqueous solution.Scientific reports · 2026Article
- Immunomodulatory and Antimicrobial Effects of Pd(II)-Pincer-Type Complex.Biomedicines · 2026Article
- Antimicrobial Activity of Metal-Based Danofloxacin Complexes Against Pathogenic Microorganisms.Molecules (Basel, Switzerland) · 2026Article
- Metal-based triazoles as a medical marvel of the modern era: a comprehensive review.RSC advances · 2026Review
- Comparative efficacy and cytocompatibility of antimicrobial nanocoatings versus antibiotics on titanium dental implant surfaces.Bioinformation · 2026Article
- Hierarchically porous copper and gallium loaded sol-gel phosphate glasses for enhancement of wound closure.Journal of materials chemistry. B · 2025Article
- Article
- Role of AprA and pyocyanin fromMicrobiology (Reading, England) · 2025Article
- Antimicrobial resistance in orthopedics: microbial insights, clinical impact, and the necessity of a multidisciplinary approach-a review.Acta orthopaedica · 2025Review
- Antibiotic resistance and pathogenicity of Shiga-toxin-producingJournal of advanced veterinary and animal research · 2025Article
- Preparation and characteristics evaluation of chitosan-coated nanoliposomes containing ferrous sulfate.Scientific reports · 2025Article
- Structural analysis of a micron-sized deposit of CuCommunications medicine · 2025Article
- A Comprehensive Review on the Importance of Sustainable Synthesized Coinage Metal Nanomaterials and Their Diverse Biomedical Applications.Biological trace element research · 2025Review
- The Fe-Cyclam-Derived Compound [Fe(cyclam)sal]PFACS omega · 2025Article
- Facile Spray-Coating of Antimicrobial Silica Nanoparticles for High-Touch Surface Protection.ACS applied materials & interfaces · 2025Article
- Synthesis and Characterization of Novel Hydrazone Complexes: Exploring DNA/BSA Binding and Antimicrobial Potential.ACS omega · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance (AMR) is one of the greatest global health challenges of modern times and its prevalence is rising worldwide. AMR within bacteria reduces the efficacy of antibiotics and increases both the morbidity and the mortality associated with bacterial infections. Despite this growing risk, few antibiotics with a novel mode of action are being produced, leading to a lack of antibiotics that can effectively treat bacterial infections with AMR. Metals have a history of antibacterial use but upon the discovery of antibiotics, often became overlooked as antibacterial agents. Meanwhile, metal-based complexes have been used as treatments for other diseases, such as the gold-containing drug auranofin, used to treat rheumatoid arthritis. Metal-based antibacterial compounds have novel modes of action that provide an advantage for the treatment of bacterial infections with resistance to conventional antibiotics. In this review, the antibacterial activity, mode of action, and potential for systemic use of a number of metal-based antibacterial complexes are discussed. The current limitations of these compounds are highlighted to determine if metal-based agents are a potential solution for the treatment of bacterial infections, especially those resistant to conventional antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.