ArticleAmerican journal of physiology. Heart and circulatory physiology2021
Calcification prevalence in different vascular zones and its association with demographics, risk factors, and morphometry.
Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies.Scientific reports · 2024Pooled it
- Biomechanical Characterization of Porcine Lower Limb Arteries for Preclinical Evaluation of Peripheral Vascular Devices.Annals of biomedical engineering · 2026Article
- Abdominal aortic tortuosity is not associated with other vascular peripheral pathologies or classical cardiovascular risk factors.Scientific reports · 2026Article
- Windkessel Preserving Aortic Stent Graft Attenuates Left Ventricular Remodelling after Thoracic Endovascular Aortic Repair in a Porcine Model.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2026Article
- Bones of contention: Hematopoietic marrow within the artery wall.JVS-vascular science · 2026Article
- Effect of stent-graft compliance on hemodynamics and aortic stiffening in an in vivo porcine study.Acta biomaterialia · 2026Article
- Vascular Calcification Patterns in the Elderly: Correlation Between Aortic and Iliac Calcification Burden.Diagnostics (Basel, Switzerland) · 2025Article
- BIOMECHANICAL CHARACTERIZATION OF PORCINE LOWER LIMB ARTERIES FOR PRECLINICAL EVALUATION OF PERIPHERAL VASCULAR DEVICES.bioRxiv : the preprint server for biology · 2025Article
- FREQUENCY OF AORTIC MISCANNULATION DURING FLUOROSCOPY-FREE ENDOVASCULAR NAVIGATION.medRxiv : the preprint server for health sciences · 2025Article
- Medial arterial calcification in ageing and disease: current evidence and knowledge gaps.European heart journal · 2025Review
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Determinants of thoracic aortic calcification and its effects on thoracic aortic size.The international journal of cardiovascular imaging · 2025Article
- Could carotid artery calcifications and pulp stones be an alarm sign for diabetes mellitus? A retrospective observational study.BMC endocrine disorders · 2025Observational
- Thoracic aortic calcifications on chest radiographs and incident major adverse limb events in cardiovascular disease patients.The international journal of cardiovascular imaging · 2025Observational
- Vascular Calcification Amplifies Limb Flexion-Induced Arterial Deformations and Causes Intermittent Vessel Pinching.Annals of surgery · 2025Article
- Large animal model of controlled peripheral artery calcification.Acta biomaterialia · 2025Article
- Variations in stiffness and structure of the human aorta along its length.Scientific reports · 2025Article
- Characterization of Atherosclerotic Plaque in Coronary CT Angiography and Some Related Factors in Patients with Coronary Artery Disease Referred to Farshchian Heart Hospital in Hamadan in 2023 :.Galen medical journal · 2025Article
- Anatomical analysis of the abdominal aorta in a South African sample: influence of age and sex.Surgical and radiologic anatomy : SRA · 2024Article
- Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle.American journal of physiology. Heart and circulatory physiology · 2024Review
Corrections and comments
- Commented on by
Authors and funding
8 authors.
Funding
Abstract
Vascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized tomography angiography scans from 211 subjects 5-93 yr old (mean age 47 ± 24 yr, 127 M/84 F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thoracic aorta to the pelvic arteries. A machine learning random forest algorithm was used to determine the associations between calcification in each zone with demographics, risk factors, and vascular morphometry. Calcification appeared during the fourth decade of life and was present in all subjects after 65 yr. The abdominal aorta and the iliofemoral segment were the first to develop calcification, whereas the ascending thoracic aorta was the last. Demographics and risk factors explained 33-59% of the variation in calcification. Age, creatinine level, body mass index, coronary artery disease, and hypertension were the strongest contributors, whereas the effects of sex, race, tobacco use, diabetes, dyslipidemia, and alcohol and substance use disorders on calcification were small. Vascular morphometry did not directly and independently affect calcium burden. Vascular zones develop calcification asynchronously, with distal segments calcifying first. Understanding the influence of demographics and risk factors on calcium prevalence can help better understand the disease pathophysiology and may help with the early identification of patients that are at higher risk of cardiovascular events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.