ArticleMagnetic resonance in medicine2021
Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 65 citations in OpenAlex.
- An Open-Source, Reproducible MRI Data Acquisition and Reconstruction Workflow Using Pulseq: Multi-Site and Cross-Vendor Validation.Magnetic resonance in medicine · 2026Article
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- Differentiation between glioblastomas and solid brain metastases using amide proton transfer-weighted (APTw) MRI with and without fluid suppression.Magma (New York, N.Y.) · 2026Article
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- PRIME: Phase reversed interleaved multi-Echo acquisition enables highly accelerated distortion-corrected diffusion MRI.Medical image analysis · 2026Article
- Harmonization in magnetic resonance imaging: A survey of acquisition, image-level, and feature-level methods.Medical image analysis · 2026Review
- Dynamic Transitions for Fast Joint Acquisition and Reconstruction of CEST-Magnetic resonance in medicine · 2026Article
- Generalization of Optimal Control Saturation Pulse Design for Robust and High CEST Contrast.Magnetic resonance in medicine · 2026Article
- Optimization of Pulsed Saturation Transfer MR Fingerprinting (ST MRF) Acquisition Using the Cramér-Rao Bound and Sequential Quadratic Programming.Magnetic resonance in medicine · 2026Article
- Prediction of MGMT promoter methylation in glioblastoma and grade 4 astrocytoma using fluid-suppressed chemical exchange saturation transfer MRI and machine learning-based segmentation.Frontiers in oncology · 2026Article
- Radiofrequency bandwidth effects in direct saturation dynamic glucose enhanced MRI at 3T.Frontiers in neuroscience · 2026Article
- Multiparametric Saturation Transfer MR Fingerprinting Using Rosette-Accelerated Readout.NMR in biomedicine · 2026Article
- Quantitative multi-metabolite imaging of Parkinson's disease using AI boosted molecular MRI.Npj imaging · 2025Article
- Multi-contrast generation and quantitative MRI using a transformer-based framework with RF excitation embeddings.Communications biology · 2025Article
- pTx-Pulseq in hybrid sequences: Accessible and advanced hybrid open-source MRI sequences on Philips scanners.Magnetic resonance in medicine · 2025Article
- Quantitative molecular imaging using deep magnetic resonance fingerprinting.Nature protocols · 2025Review
- Vendor-agnostic 3D multiparametric relaxometry improves cross-platform reproducibility.Magnetic resonance in medicine · 2025Article
- Dynamic glucose enhanced imaging using direct water saturation.Magnetic resonance in medicine · 2025Article
- The Pulseq-CEST Library: definition of preparations and simulations, example data, and example evaluations.Magma (New York, N.Y.) · 2025Article
- MRI acquisition and reconstruction cookbook: recipes for reproducibility, served with real-world flavour.Magma (New York, N.Y.) · 2025Review
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 4 countries.
Funding
Abstract
purposeAs the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.
methodsWe present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human-readable CEST protocols can be shared; (2) an open-source Bloch-McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be combined with any existing readout module.
resultsThe exact definition of the CEST preparation period, in combination with the flexible simulation, leads to a good match between simulations and measurements. The standard allowed finding consensus on three amide proton transfer-weighted protocols that could be compared in healthy subjects and a tumor patient. In addition, we could show coherent multisite results for a sophisticated CEST method, highlighting the benefits regarding protocol sharing and reproducibility.
conclusionWith Pulseq-CEST, we provide a straightforward approach to standardize, share, simulate, and measure different CEST preparation schemes, which are inherently completely defined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.