ArticleMethods in molecular biology (Clifton, N.J.)2021
Phylogenetic Methods for Genome-Wide Association Studies in Bacteria.
Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Phylogenetic Relationships and Structural Conservation ofInternational journal of molecular sciences · 2026Article
- Article
- Migration Rates on Swim Plates Vary between Escherichia coli Soil Isolates: Differences Are Associated with Variants in Metabolic Genes.Applied and environmental microbiology · 2023Article
- A graph-based approach for the visualisation and analysis of bacterial pangenomes.BMC bioinformatics · 2022Article
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Abstract
Genome-wide association studies in bacteria have great potential to deliver a better understanding of the genetic basis of many biologically important phenotypes, including antibiotic resistance, pathogenicity, and host adaptation. Such studies need however to account for the specificities of bacterial genomics, especially in terms of population structure, homologous recombination, and genomic plasticity. A powerful way to tackle this challenge is to use a phylogenetic approach, which is based on long-standing methodology for the evolutionary analysis of bacterial genomic data. Here we present both the theoretical and practical aspects involved in the use of phylogenetic methods for bacterial genome-wide association studies.
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