ArticleSleep & breathing = Schlaf & Atmung2022
Endothelial dysfunction in obstructive sleep apnea patients.
Article in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The effect of drug-induced sleep endoscopy on surgical outcomes for obstructive sleep apnea: a systematic review.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Pooled it
- Trial
- Obstructive sleep apnea in patients with acute myocardial infarction: one-year follow-up study.Sleep & breathing = Schlaf & Atmung · 2026Article
- The interconnection between obstructive sleep apnoea and spondyloarthritis: pathophysiology, clinical evidence, and future perspectives.Rheumatology international · 2026Review
- Improved hemodynamic and cardiorespiratory instability with vitamin D supplementation in an obstructive sleep apnea rat models.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Article
- Dose-dependent vitamin D3 supplementation attenuates endothelial dysfunction and renal injury in an obstructive sleep apnea rat model.Frontiers in pharmacology · 2026Article
- The correlation between reactive hyperemia index and endothelial dysfunction markers in patients with hypertension and obstructive sleep apnea syndrome: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Neuro-Ophthalmological Disorders Associated with Obstructive Sleep Apnoea.International journal of molecular sciences · 2025Review
- Increased serum anti-ceramide antibodies and decreased sphingosine-1-phosphate levels in patients with obstructive sleep apnea syndrome as potential markers of endothelial dysfunction.Frontiers in molecular biosciences · 2025Article
- Sleep apnoea, cognition and aspirin's effects in healthy older people: an ASPREE substudy.ERJ open research · 2025Article
- Obstructive sleep apnea -related hypertension: a review of the literature and clinical management strategy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Sleep and periodontal health.Periodontology 2000 · 2024Review
- Sleep Disordered Breathing and Neurocognitive Disorders.Journal of clinical medicine · 2024Review
- Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea.Antioxidants (Basel, Switzerland) · 2024Article
- NoSAS score predicts cardiovascular disease in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Up-to-date advance in the relationship between OSA and stroke: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Review
- Effect of obstructive sleep apnea on prognosis in patients with acute coronary syndromes with varying numbers of standard modifiable risk factors: insight from the OSA-ACS study.Journal of thrombosis and thrombolysis · 2023Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular diseases. The aim of the study was to assess the influence of OSAS on endothelial dysfunction and thrombosis biomarkers and to evaluate the effect of treatment with continuous positive airway pressure (CPAP) on biomarker levels.
methodsNT-proBNP, sICAM-1, endothelin-1, von Willebrand factor, D-dimers, and thrombin-antithrombin complex (TAT) were measured in 50 patients diagnosed with moderate-to-severe OSAS. All patients underwent transthoracic echocardiography, and 38 months after the inclusion, 16 CPAP users and 22 non-CPAP users were reassessed.
resultsSleep-related indices of apnea-hypopnea index (AHI) and mean SpO
conclusionSevere OSAS influences endothelial damage as manifested by an increase in sICAM-1 levels. Changes in right ventricular structure and function, observed mainly in patients with higher TAT and endothelin-1 levels, are also manifested by an increase in NT-proBNP levels. Long-term CPAP treatment does not seem to influence biomarkers in patients with moderate-to-severe OSAS, which may help to explain the lack of influence of CPAP on cardiovascular risk reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.