Evidence map›Paper›PMID 33961144›Full record

ReviewCurrent pain and headache reports2021

Flavonoids in the Treatment of Neuropathic Pain.

Prashant N Rao, Ojas Mainkar, Nitin Bansal, Neal Rakesh, Paul Haffey, Ivan Urits, Vwaire Orhurhu, Alan D Kaye, Richard D Urman, Amitabh Gulati and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Prashant N RaoDepartment of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA.
Ojas MainkarDepartment of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA.
Nitin BansalDepartment of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA.
Neal RakeshDepartment of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA.
Paul HaffeyDepartment of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA.
Ivan UritsSouthcoast Health, Southcoast Health Physicians Group, New Bedford, MA, USA.
Vwaire OrhurhuMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Shreveport, Shreveport, LA, USA.
Richard D UrmanDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Amitabh GulatiMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Mark JonesDepartment of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA. mrj9011@nyp.org.ORCID http://orcid.org/0000-0002-4781-2167
Cornell University · USLouisiana State University in Shreveport · USBrigham and Women's Hospital · USHarvard University · USMemorial Sloan Kettering Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewChronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain. RECENT

findingsFlavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6. Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.

Indexed as

FlavonoidsHumansNeuralgiaFlavonoidsChronic painFlavonoidsNeuroinflammationNeuropathic painTreatment

Identifiers

PMID33961144
OpenAlexW3157329682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.