ReviewCurrent cardiology reports2021
Loneliness and Risk for Cardiovascular Disease: Mechanisms and Future Directions.
Review in Current cardiology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review.Journal of the American Heart Association · 2023Pooled it
- Age-Moderated Associations Between Social Support and Loneliness in Latino Adults with Cardiovascular Disease.Hispanic health care international : the official journal of the National Association of Hispanic Nurses · 2026Article
- Bidirectional associations between loneliness and physical multimorbidity and the mediating role of social inactivity.Nature communications · 2026Article
- The Effects of Open-World and Fun, Accessible Games on Perceived Loneliness and Stoicism in Adults: Cross-Sectional Survey Study.JMIR serious games · 2026Article
- Coronary Artery Disease and Loneliness: A Cross-Sectional Analysis using the Revised UCLA Loneliness Scale.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026Article
- Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrix.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cross-Sectional and Longitudinal Associations Among Loneliness, Depression/Anxiety, and the Subjective and Chronological Age Difference in Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Social Determinants of Health and Effects on Cardiovascular Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026Review
- Joint trajectories of loneliness and depressive symptoms and risk of incident osteoporosis among middle-aged and older adults: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Social isolation and loneliness: an integration framework for medical education.Frontiers in medicine · 2026Article
- Loneliness and cognitive aging: a brain-heart axis perspective on a modifiable risk.Frontiers in aging · 2026Review
- Mapping loneliness prevention and alleviation interventions: a comparative survey of Basel, Bern, Zurich, and Dublin.Frontiers in public health · 2026Article
- Socioeconomic status does not influence quality of life and mood outcomes after catheter ablation for atrial fibrillation: A call for equitable access.Heart rhythm O2 · 2026Article
- Loneliness and all-cause mortality in the United States.PloS one · 2026Article
- Association of loneliness with incident cardiovascular diseases in middle-aged and older Chinese adults.PloS one · 2026Article
- Loneliness Prevalence and Correlates Among Community-Dwelling Older Adults in Taiwan: Clinical Utility of Brief Screening Measures.Clinical interventions in aging · 2026Article
- Atherogenic Dyslipidemia and Its Association withInternational journal of molecular sciences · 2025Article
- Conceptualising workplace loneliness: a qualitative investigation with UK workers.Social psychiatry and psychiatric epidemiology · 2025Article
- The relationship between social isolation, depressive symptoms and cognitive function in older adults: a longitudinal mediation study in China.Social psychiatry and psychiatric epidemiology · 2025Article
- Predictive role of loneliness on mortality before the age 85 years among mid- to later-life adults in the United States: a 10-year retrospective cohort study.Epidemiology and psychiatric sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewIn this review, we synthesise recent research on the association between loneliness and cardiovascular disease (CVD). We present evidence for mechanisms underlying this association and propose directions for future research. RECENT
findingsLoneliness is related to increased risk of early mortality and CVD comparable to other well-established risk factors such as obesity or smoking. Loneliness has been linked to higher rates of incident CVD, poorer CVD patient outcomes, and early mortality from CVD. Loneliness likely affects risk for these outcomes via health-related behaviours (e.g. physical inactivity and smoking), biological mechanisms (e.g. inflammation, stress reactivity), and psychological factors (e.g. depression) to indirectly damage health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.