ArticleeLife2021
fMRI-based detection of alertness predicts behavioral response variability.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Forecasting Perception Before It Happens: Context-Specific Connectivity Patterns Predict Perceptual Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Global cortical arousal effects in fMRI reveal brain markers of state and trait anxiety.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Brain network dynamics in the wake-sleep transition reorganize according to task engagement.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Multimodal PET/MR imaging of prolonged disorders of consciousness: a pilot feasibility study.Frontiers in neuroscience · 2026Article
- Article
- Patterns of brain-wide associations reflect socioeconomics.bioRxiv : the preprint server for biology · 2025Article
- Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics.Nature communications · 2025Article
- Functional MRI signals as fast as 1Hz are coupled to brain states and predict spontaneous neural activity.bioRxiv : the preprint server for biology · 2025Article
- Autonomic physiological coupling of the global fMRI signal.Nature neuroscience · 2025Article
- The functional overlap between respiration and global signal and its behavioral relevance.Communications biology · 2025Article
- Sensory Encoding Alternates With Hippocampal Ripples across Cycles of Forebrain Spiking Cascades.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Widespread Autonomic Physiological Coupling Across the Brain-Body Axis.bioRxiv : the preprint server for biology · 2024Article
- Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review.Brain sciences · 2024Review
- Functional MRI signals exhibit stronger covariation with peripheral autonomic measures as vigilance decreases.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Resting-state global brain activity induces bias in fMRI motion estimates.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Challenges in the measurement and interpretation of dynamic functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Intrinsic forebrain arousal dynamics governs sensory stimulus encoding.bioRxiv : the preprint server for biology · 2023Article
- Why is everyone talking about brain state?Trends in neurosciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Levels of alertness are closely linked with human behavior and cognition. However, while functional magnetic resonance imaging (fMRI) allows for investigating whole-brain dynamics during behavior and task engagement, concurrent measures of alertness (such as EEG or pupillometry) are often unavailable. Here, we extract a continuous, time-resolved marker of alertness from fMRI data alone. We demonstrate that this fMRI alertness marker, calculated in a short pre-stimulus interval, captures trial-to-trial behavioral responses to incoming sensory stimuli. In addition, we find that the prediction of both EEG and behavioral responses during the task may be accomplished using only a small fraction of fMRI voxels. Furthermore, we observe that accounting for alertness appears to increase the statistical detection of task-activated brain areas. These findings have broad implications for augmenting a large body of existing datasets with information about ongoing arousal states, enriching fMRI studies of neural variability in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.