ArticleJournal of diabetes investigation2021
Adverse obstetric outcomes in early-diagnosed gestational diabetes mellitus: The Japan Environment and Children's Study.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Early-Onset Versus Late-Onset Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Maternal, Perinatal and Neonatal Outcomes.Diabetes, obesity & metabolism · 2026Pooled it
- Does fasting plasma glucose values 5.1-5.6 mmol/l in the first trimester of gestation a matter?Frontiers in endocrinology · 2023Trial
- Reduced serum acetyl-L-carnitine is associated with hypertensive disorders in women with gestational diabetes mellitus: a multi-omics study.Cardiovascular diabetology · 2026Article
- Public Health-Relevant Factors Associated with Gestational Diabetes Mellitus and Obstetric Outcomes: A Case-Control Study from Kazakhstan.International journal of environmental research and public health · 2026Article
- Machine Learning-Based Early Prediction of Gestational Diabetes Using First-Trimester Laboratory Parameters.Cureus · 2026Article
- Barriers and facilitators to attending postpartum diabetes screening among women with previous gestational diabetes in China: A qualitative analysis.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Glucose variability as a key mediator in the relationship between pre-pregnancy overweight/obesity and late-onset hypertensive disorders of pregnancy.Scientific reports · 2025Article
- Impact of maternal overweight/obesity and high fasting plasma glucose on adverse perinatal outcomes in early gestational diabetes mellitus.Journal of diabetes investigation · 2025Article
- Association of early onset gestational diabetes mellitus with postpartum glucose intolerance.Diabetology international · 2025Article
- Matsuda index adjusted for sustained hyperglycemia via propensity scores outperforms homeostatic model assessment for insulin resistance in identifying insulin-requiring gestational diabetes mellitus.SAGE open medicine · 2025Article
- Clinical challenges in early pregnancy in Japan: An update on gestational diabetes.Journal of diabetes investigation · 2024Article
- Complications and risk factors of early-onset versus late-onset gestational diabetes mellitus: A cohort study from Saudi Arabia.Saudi medical journal · 2023Article
- Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study.Diabetology & metabolic syndrome · 2023Article
- Article
- Updates for hyperglycemia in pregnancy: The ongoing journey for maternal-neonatal health.Journal of diabetes investigation · 2022Article
- Gestational weight gain as a risk factor for dystocia during first delivery: a multicenter retrospective cohort study in Japan.BMC pregnancy and childbirth · 2022Article
- Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children's Study.BMC pregnancy and childbirth · 2022Article
- Risk of Adverse Pregnancy Outcomes in Young Women with Thyroid Cancer: A Systematic Review and Meta-Analysis.Cancers · 2022Review
- Association of glycated hemoglobin at an early stage of pregnancy with the risk of gestational diabetes mellitus among non-diabetic women in Japan: The Japan Environment and Children's Study.Journal of diabetes investigation · 2022Article
- Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
AIMS/
introductionTo examine adverse outcomes in women with early-diagnosed gestational diabetes mellitus using data from a large birth cohort study in Japan. MATERIALS AND
methodsThis study analyzed data from singleton pregnancies in the Japan Environment and Children's Study including births during 2011-2014. Mothers with an HbA1c level ≥6.5% in the first trimester, a history of diabetes mellitus, or steroid use during pregnancy were excluded. The participants were divided into three groups: control (without gestational diabetes mellitus), early-diagnosed gestational diabetes mellitus (diagnosed before gestational week 24), and late-diagnosed gestational diabetes mellitus (diagnosed after gestational week 24). Multiple logistic regression analysis was performed to calculate the risk of early-diagnosed and late-diagnosed gestational diabetes mellitus for adverse obstetrics outcomes.
resultsIn total, 100,376 eligible participants were included in this study. The number of individuals in control cases, early-diagnosed gestational diabetes mellitus cases, and late-diagnosed gestational diabetes mellitus cases was 98,090 (97.7%), 751 (0.7%), and 1,535 (1.5%), respectively. When control cases were used as reference, multiple logistic regression analysis revealed that early-diagnosed gestational diabetes mellitus increased the risk of hypertensive disorders of pregnancy (adjusted odds ratio: 2.08, 95% confidence interval: 1.51-2.86), early-onset hypertensive disorders of pregnancy (adjusted odds ratio: 1.91, 95% confidence interval: 1.01-3.65), and late-onset hypertensive disorders of pregnancy (adjusted odds ratio: 1.92, 95% confidence interval: 1.29-2.86).
conclusionEarly-diagnosed gestational diabetes mellitus is associated with serious obstetric complications. Our findings indicate the necessity of further investigations to validate the benefit of early screening for gestational diabetes mellitus in pregnant women.
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