Evidence map›Paper›PMID 33960434›Full record

ArticleAnnals of the New York Academy of Sciences2021

Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells.

Antonella Muscella, Erika Stefàno, Luigi De Bellis, Eliana Nutricati, Carmine Negro, Santo Marsigliante

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the New York Academy of Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Evaluating the Therapeutic Potential of Common Sage (Molecules (Basel, Switzerland) · 2026
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  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Antonella MuscellaDepartment of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Lecce, Italy.ORCID 0000-0002-2822-9929
Erika StefànoDepartment of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Lecce, Italy.
Luigi De BellisDepartment of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Lecce, Italy.ORCID 0000-0002-6047-3526
Eliana NutricatiDepartment of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Lecce, Italy.ORCID 0000-0002-1197-5693
Carmine NegroDepartment of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Lecce, Italy.ORCID 0000-0001-6981-2216
Santo MarsiglianteDepartment of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Lecce, Italy.ORCID 0000-0001-6535-3286
University of Salento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salvia clandestina L. is a wild perennial species present in the Salento area of Italy. Here, we examined the in vitro effects of an aqueous extract of S. clandestina L. on the MG-63 osteosarcoma cell line. The extract reduced osteosarcoma cell viability mainly by way of apoptosis, as we observed (1) upregulation of gene and protein expression of p53, cyclin-dependent kinase inhibitors p21

Indexed as

Antineoplastic Agents, PhytogenicApoptosisBone NeoplasmsCell CycleCell Line, TumorCell ProliferationChromatography, High Pressure LiquidDose-Response Relationship, DrugEpithelial-Mesenchymal TransitionHumansMatrix MetalloproteinasesModels, BiologicalOsteosarcomaPlant ExtractsSalviaSignal TransductionAntineoplastic Agents, PhytogenicMatrix MetalloproteinasesPlant Extractsapoptosisdanshensuepithelial-to-mesenchymal transitionMAPKsMG-63 osteosarcomaMMPsphenolic compoundsSalvia clandestina L.

Identifiers

PMID33960434
PMCPMC8518948
OpenAlexW3157496955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.