Evidence map›Paper›PMID 33960251›Full record

ArticleDrug delivery2021

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug.

Wei Xin, Yumei Wang, Yan Bian, Jiahui Lin, Wenhao Weng, Xinyi Zhao, Kaijun Gou, Xianmou Guo, Heran Li

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wei XinSchool of Pharmacy, China Medical University, Shenyang, China.
Yumei WangSchool of Pharmacy, China Medical University, Shenyang, China.
Yan BianSchool of Pharmacy, China Medical University, Shenyang, China.
Jiahui LinSchool of Pharmacy, China Medical University, Shenyang, China.
Wenhao WengSchool of Pharmacy, China Medical University, Shenyang, China.
Xinyi ZhaoSchool of Pharmacy, China Medical University, Shenyang, China.
Kaijun GouSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Xianmou GuoSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Heran LiSchool of Pharmacy, China Medical University, Shenyang, China.
China Medical University · CNShenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex associated of tartaric acid and polyethyleneimine (PEIs) as templates, scaffolds and catalysts. The structural features including morphology, size, pore structure and texture properties were systematacially studied. The results showed that PEIs@TA-CMS was monodispersed spherical nanoparticles in a uniformed diameter of 120-130 nm with well-developed pore structure (S

Indexed as

Administration, OralAnimalsChemistry, PharmaceuticalDrug CarriersDrug LiberationMaleNanoparticlesNimodipineParticle SizePolyethyleneimineRatsRats, Sprague-DawleySilicon DioxideSolubilitySurface PropertiesTartratesDrug CarriersNimodipinePolyethyleneimineSilicon Dioxidetartaric acidTartratesBiomimetic synthesischiral mesoporous silicadrug deliverynimodipineoral bioavailability

Identifiers

PMID33960251
PMCPMC8118497
OpenAlexW3158227359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.