Evidence map›Paper›PMID 33959907›Full record

ArticleAdvances in experimental medicine and biology2021

Urinary Markers of Podocyte Dysfunction in Chronic Glomerulonephritis.

Natalia Chebotareva, Irina Bobkova, Lidia Lysenko, Sergey Moiseev

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natalia ChebotarevaTareev Clinic, Department of Nephrology, Sechenov First Moscow State Medical University, Moscow, Russia. natasha_tcheb@mail.ru.
Irina BobkovaTareev Clinic, Department of Nephrology, Sechenov First Moscow State Medical University, Moscow, Russia.
Lidia LysenkoTareev Clinic, Department of Nephrology, Sechenov First Moscow State Medical University, Moscow, Russia.
Sergey MoiseevTareev Clinic, Department of Nephrology, Sechenov First Moscow State Medical University, Moscow, Russia.
Sechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic glomerulonephritis (CGN) is a disease with a steady progressive course that involves the development of nephrosclerosis, which is especially evident in clinical courses with incidences of high proteinuria (PU). Currently, proteinuria is considered the main laboratory feature (sign) of CGN activity and progression because proteinuria is closely related to the process of tubulointerstitial fibrosis, which is correlated with the grade of renal insufficiency. The injury to podocytes, which are key components of the filtration barrier, plays a central role in proteinuria development. The detachment of podocytes from the glomerular basement membrane leading to podocytopenia is suggested to induce glomerulosclerosis and hyalinosis with obliteration of capillary loops and the progression of chronic kidney disease. Urinary markers of podocyte dysfunction could serve as useful tools while monitoring the activity and prognosis of CGN. In this chapter, the most important mechanisms of podocyte loss and urinary markers of this process are discussed.

Indexed as

GlomerulonephritisPodocytesBiomarkersChronic DiseaseHumansProteinuriaBiomarkersChronic glomerulonephritisHeat shock proteinsMatrix metalloproteinasesNephrinuriaPodocytopeniaPodocyturiaUrinary biomarkersVEGFWT-1

Identifiers

PMID33959907
OpenAlexW3159531512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.