SynthesisNeuropsychology review2022
Saccadic Eye Movement in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Synthesis in Neuropsychology review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Portable eye-tracking in neurology: current uses and future perspectives in cognition.Arquivos de neuro-psiquiatria · 2026Pooled it
- Innovations in dementia screening: a systematic review and meta-analysis of virtual reality assessments.Frontiers in psychology · 2025Pooled it
- Naturalistic Eye Movement Tasks in Parkinson's Disease: A Systematic Review.Journal of Parkinson's disease · 2024Pooled it
- The application of saccades to assess cognitive impairment among older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Eye-tracking training improves the learning and memory of children with learning difficulty.Scientific reports · 2022Trial
- Article
- Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy.Diagnostics (Basel, Switzerland) · 2026Review
- Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Association between Saccadic Eye Movement Parameters and Mild Cognitive Impairment: The Nagahama Study.Ophthalmology science · 2026Article
- Pupillary Light Reflex and Eye Movement Parameters as Objective Measures of Cognitive Decline in Older Adults: A Secondary Analysis of a Multimodal Public Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- The oculomotor cost of hypocapnic hyperventilation.The Journal of physiology · 2026Article
- Exploring Alzheimer Disease from a Retinal and Ocular Perspective.Biomedicines · 2026Review
- Machine Learning Integration of Eye-Tracking and Cognitive Screening for Detecting Cognitive Impairment.Journal of eye movement research · 2026Article
- Effects of an Eye-Tracking Digital Serious Game on Cognitive Function in Mild Cognitive Impairment: Pilot Intervention Study.JMIR formative research · 2026Article
- Normative Values for Prosaccade and Antisaccade Eye Movements in Adolescents Using a New Saccadometry Test.Journal of the American Academy of Audiology · 2026Article
- Application of Deep Multi-Scale Representation Learning Based on Eye-Tracking and Facial Expression Data in Cognitive Decline Assessment.Sensors (Basel, Switzerland) · 2026Article
- Cognitive Vergence and Pupillary Responses as Functional Oculomotor Signatures to Differentiate AT(N) Biological Profiles.bioRxiv : the preprint server for biology · 2026Article
- Cognitive Vergence and Pupil Response During Oddball Task are Associated With Alzheimer's Disease Cerebrospinal Fluid Neurodegenerative Biomarkers.bioRxiv : the preprint server for biology · 2026Article
- Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- How breathing disrupts vision: hyperventilation-induced hypocapnia impairs oculomotor responses in resting humans.The Journal of physiology · 2026Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the leading cause of dementia, and mild cognitive impairment (MCI) is considered the transitional state to AD dementia (ADD) and other types of dementia, whose symptoms are accompanied by altered eye movement. In this work, we reviewed the existing literature and conducted a meta-analysis to extract relevant eye movement parameters that are significantly altered owing to ADD and MCI. We conducted a systematic review of 35 eligible original publications in saccade paradigms and a meta-analysis of 27 articles with specified task conditions, which used mainly gap and overlap conditions in both prosaccade and antisaccade paradigms. The meta-analysis revealed that prosaccade and antisaccade latencies and frequency of antisaccade errors showed significant alterations for both MCI and ADD. First, both prosaccade and antisaccade paradigms differentiated patients with ADD and MCI from controls, however, antisaccade paradigms was more effective than prosaccade paradigms in distinguishing patients from controls. Second, during prosaccade in the gap and overlap conditions, patients with ADD had significantly longer latencies than patients with MCI, and the trend was similar during antisaccade in the gap condition as patients with ADD had significantly more errors than patients with MCI. The anti-effect magnitude was similar between controls and patients, and the magnitude of the latency of the gap effect varied among healthy controls and MCI and ADD subjects, but the effect size of the latency remained large in both patients. These findings suggest that, using gap effect, anti-effect, and specific choices of saccade paradigms and conditions, distinctions could be made between MCI and ADD patients as well as between patients and controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.