ArticleBrain communications2021
Strengthened structure-function relationships of the corticospinal tract by free water correction after stroke.
Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- MEP Status is Not Predictive of Response to Upper Limb Training in People With Chronic, Moderate-Severe Hemiparesis Post-Stroke.Neurorehabilitation and neural repair · 2025Trial
- Longitudinal microstructural alterations surrounding subcortical ischemic stroke lesions detected by free-water imaging.Human brain mapping · 2024Article
- Effect of non-invasive transcutaneous auricular vagus nerve stimulation on cerebral motor excitability-Study protocol for a randomized, sham controlled trial.Frontiers in neurology · 2023Article
- Structure of the Motor Descending Pathways Correlates with the Temporal Kinematics of Hand Movements.Biology · 2022Article
- Corticospinal excitability and conductivity are related to the anatomy of the corticospinal tract.Brain structure & function · 2022Article
- Home-based portable fNIRS-derived cortical laterality correlates with impairment and function in chronic stroke.Frontiers in human neuroscience · 2022Article
- Remote cortical atrophy and language outcomes after chronic left subcortical stroke with aphasia.Frontiers in neuroscience · 2022Article
- Relationship Between Cortical Excitability Changes and Cortical Thickness in Subcortical Chronic Stroke.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The corticospinal tract is the most intensively investigated tract of the human motor system in stroke rehabilitative research. Diffusion-tensor-imaging gives insights into its microstructure, and transcranial magnetic stimulation assesses its excitability. Previous data on the interrelationship between both measures are contradictory. Correlative or predictive models which associate them with motor outcome are incomplete. Free water correction has been developed to enhance diffusion-tensor-imaging by eliminating partial volume with extracellular water, which could improve capturing stroke-related microstructural alterations, thereby also improving structure-function relationships in clinical cohorts. In the present cross-sectional study, data of 18 chronic stroke patients and 17 healthy controls, taken from a previous study on cortico-cerebellar motor tracts, were re-analysed: The data included diffusion-tensor-imaging data quantifying corticospinal tract microstructure with and without free water correction, transcranial magnetic stimulation data assessing recruitment curve properties of motor evoked potentials and detailed clinical data. Linear regression modelling was used to interrelate corticospinal tract microstructure, recruitment curves properties and clinical scores. The main finding of the present study was that free water correction substantially strengthens structure-function associations in stroke patients: Specifically, our data evidenced a significant association between fractional anisotropy of the ipsilesional corticospinal tract and its excitability (
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