Evidence map›Paper›PMID 33959688›Full record

ArticleCurrent opinion in biomedical engineering2021

A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI.

Philipp Mächler, Thomas Broggini, Celine Mateo, Martin Thunemann, Natalie Fomin-Thunemann, Patrick R Doran, Ikbal Sencan, Kivilcim Kilic, Michèle Desjardins, Hana Uhlirova and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. WidefieldNeurophotonics · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Philipp MächlerDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Thomas BrogginiDepartment of Physics, University of California San Diego, La Jolla, CA 92093, USA.
Celine MateoDepartment of Physics, University of California San Diego, La Jolla, CA 92093, USA.
Martin ThunemannDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Natalie Fomin-ThunemannDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Patrick R DoranDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Ikbal SencanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Kivilcim KilicDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Michèle DesjardinsDépartement de Physique, de Génie Physique et d'Optique, Université Laval, Québec, QC G1V 0A6, Canada.
Hana UhlirovaInstitute of Scientific Instruments of the Czech Academy of Science, Brno, Czech Republic.
Mohammad A YaseenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.
David A BoasDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Andreas A LinningerDepartment of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Massimo VergassolaDepartment of Physics, University of California San Diego, La Jolla, CA 92093, USA.
Xin YuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Laura D LewisDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Jonathan R PolimeniAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Bruce R RosenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Sava SakadžićAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Richard B BuxtonDepartment of Radiology, University of California San Diego, La Jolla, CA 92037, USA.
Martin LauritzenDepartment of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen N 2200, Denmark.
David KleinfeldDepartment of Physics, University of California San Diego, La Jolla, CA 92093, USA.
Anna DevorDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Funding

Resilient versus fragile aspects of blood flow in the mammalian brainR35NS097265 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2017 to 2024
$6.8M
MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
Resting state connectivity: Biophysical basis for and improved fMRI measurementsR01MH111438 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID, ROSEN, BRUCE R · 2016 to 2020
$5.2M
The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneityR01NS108472 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, SCHAFFER, CHRIS B · 2018 to 2022
$3.2M
Relating Neuroimmune and Neurovascular Alterations During Alzheimer's Disease ProgressionR01AA027097 · NIAAA · NORTHEASTERN UNIVERSITY · PI YASEEN, MOHAMMAD ABBAS · 2018 to 2022
$2.7M
Two-Photon Microscopy of Oxygen Consumption in the BrainR01NS091230 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA · 2015 to 2019
$2.4M
Develop a multi-modal cross-scale fMRI platform with laminar-specific cellular recordings through multi-channel tapered photonic crystal fiber arrayRF1NS113278 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, XIN · 2019 to 2019
$2.0M
Effects of intrinsic and drug-induced neuromodulation on functional brain imagingR01DA050159 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2020 to 2024
$1.9M
Bridging the cellular and microvascular anatomy and functional dynamics: Upgrade the 14T horizontal MR for rodent and ex-vivo imagingS10MH124733 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R, YU, XIN · 2020 to 2020
$600k
Exploring preclinical amyloid pathology with optical microscopyR56AG058849 · NIA · NORTHEASTERN UNIVERSITY · PI YASEEN, MOHAMMAD ABBAS · 2019 to 2019
$432k
NIAAA NIH HHS R01 AA027097NIA NIH HHS R56 AG058849NIDA NIH HHS R01 DA050159NIMH NIH HHS R01 MH111359NIMH NIH HHS R01 MH111438NIMH NIH HHS S10 MH124733NINDS NIH HHS R01 NS091230NINDS NIH HHS R01 NS108472NINDS NIH HHS R35 NS097265NINDS NIH HHS RF1 NS113278
6 · The paper itself

Abstract

Recent developments in optical microscopy, applicable for large-scale and longitudinal imaging of cortical activity in behaving animals, open unprecedented opportunities to gain a deeper understanding of neurovascular and neurometabolic coupling during different brain states. Future studies will leverage these tools to deliver foundational knowledge about brain state-dependent regulation of cerebral blood flow and metabolism as well as regulation as a function of brain maturation and aging. This knowledge is of critical importance to interpret hemodynamic signals observed with functional magnetic resonance imaging (fMRI).

Indexed as

CMRO2glycolysishemodynamicneuromodulationoptical imaging

Identifiers

PMID33959688
PMCPMC8095678

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.