Evidence map›Paper›PMID 33959502›Full record

ArticleFrontiers in oncology2021

c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study.

Nathalie Faumont, Oussama Taoui, Davi Collares, Jean-Philippe Jais, Karen Leroy, Léa Prévaud, Fabrice Jardin, Thierry J Molina, Christiane Copie-Bergman, Barbara Petit and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. HemaSphere · 2026
    Article
  2. Article
  3. B-cell-specificBlood neoplasia · 2025
    Article
  4. Computational modelling of aggressive B-cell lymphoma.Biochemical Society transactions · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 1 country.

Nathalie FaumontCNRS UMR-7276, INSERM U1262, CRIBL, University of Limoges, and Hematology Laboratory of Dupuytren Hospital University Center (CHU) of Limoges, Limoges, France.
Oussama TaouiCNRS UMR-7276, INSERM U1262, CRIBL, University of Limoges, and Hematology Laboratory of Dupuytren Hospital University Center (CHU) of Limoges, Limoges, France.
Davi CollaresUniversité de Paris, NF-κappaB, Differentiation and Cancer, Paris, France.
Jean-Philippe JaisBiostatistics Department, Imagine Institute, Paris, France.
Karen LeroyUMRS1138, Centre de Recherche des Cordeliers, Paris Descartes University, CARPEM, Department of Genetics and Molecular Biology, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.
Léa PrévaudCNRS UMR-7276, INSERM U1262, CRIBL, University of Limoges, and Hematology Laboratory of Dupuytren Hospital University Center (CHU) of Limoges, Limoges, France.
Fabrice JardinInserm U1245 and Department of Henri-Becquerel Hematology Center and Normandie Univ UNIROUEN, Rouen, France.
Thierry J MolinaUniversité de Paris, NF-κappaB, Differentiation and Cancer, Paris, France.
Christiane Copie-BergmanIMRB-Inserm U955, AP-HP Henri-Mondor Hospital, Créteil, France.
Barbara PetitPathology Department, CHU of Limoges, Limoges, France.
Marie-Pierre GourinRegional Reference Structure of Limousin Lymphomas, Clinical Hematology Department, CHU of Limoges, Limoges, France.
Dominique BordessouleCNRS UMR-7276, INSERM U1262, CRIBL, University of Limoges, and Hematology Laboratory of Dupuytren Hospital University Center (CHU) of Limoges, Limoges, France.
Danielle TroutaudEA3842, CAPTuR, University of Limoges, Limoges, France.
Véronique BaudUniversité de Paris, NF-κappaB, Differentiation and Cancer, Paris, France.
Jean FeuillardCNRS UMR-7276, INSERM U1262, CRIBL, University of Limoges, and Hematology Laboratory of Dupuytren Hospital University Center (CHU) of Limoges, Limoges, France.
Université de Limoges · FRUniversité Paris Cité · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Universitaire de Limoges · FRCentre National de la Recherche Scientifique · FRContrôle de la Réponse Immune B et Lymphoproliférations · FRDélégation Paris 5 · FRInserm · FRInstitut des Maladies Génétiques Imagine · FRInstitut Mondor de Recherche Biomédicale · FRLimousin Regional Council · FRUniversité de Rouen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relationships between c-Rel and GCB-DLBCLs remain unclear. We found that strong c-Rel DNA-binding activity was mostly found in GCBs on two independent series of 48 DLBCLs and 66 DLBCLs, the latter issued from the GHEDI series. c-Rel DNA-binding activity was associated with increased

Indexed as

c-RelDNA binding activitygenetic alterationsgerminal center B-cell–diffuse large B-cell lymphomaNF-kappaB

Identifiers

PMID33959502
PMCPMC8095348
OpenAlexW3152919681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.