ArticleVirus evolution2021
Characterization of the gut DNA and RNA Viromes in a Cohort of Chinese Residents and Visiting Pakistanis.
Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- A meta-analysis of infant gut viromes reveals global patterns in bacteriophage community assembly and functional capacity over the first three years of life.Nature communications · 2026Pooled it
- Relationship between gut microbiota and osteoarthritis: a scientometric analysis.Frontiers in microbiology · 2025Pooled it
- Trial
- Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome.Microbiology spectrum · 2021Trial
- Metatranscriptomics reveals the horse gut RNA virome and a viral sharing network with human and domestic animals.Frontiers in veterinary science · 2026Article
- Article
- Characteristics of the gut virome in patients with premalignant colorectal adenoma.Journal of translational medicine · 2025Article
- The Chinese gut virus catalogue reveals gut virome diversity and disease-related viral signatures.Genome medicine · 2025Article
- Characterizations of gut bacteriome, mycobiome, and virome of healthy individuals living in sea-level and high-altitude areas.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- The gut and circulating virome: emerging players in aging and longevity.Frontiers in aging · 2025Review
- A metagenome-wide study of the gut virome in chronic kidney disease.Theranostics · 2025Article
- A multi-kingdom collection of 33,804 reference genomes for the human vaginal microbiome.Nature microbiology · 2024Article
- Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.Microbiome · 2024Article
- Distinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis.Journal of translational medicine · 2024Article
- Deep metagenomic characterization of the gut virome in pregnant women with preeclampsia.mSphere · 2024Article
- Comparative analysis of the vaginal bacteriome and virome in healthy women living in high-altitude and sea-level areas.European journal of medical research · 2024Article
- Structural changes in the gut virome of patients with atherosclerotic cardiovascular disease.Microbiology spectrum · 2024Article
- Characterizations of the multi-kingdom gut microbiota in Chinese patients with gouty arthritis.BMC microbiology · 2023Article
- Optimization and evaluation of viral metagenomic amplification and sequencing procedures toward a genome-level resolution of the human fecal DNA virome.Journal of advanced research · 2023Article
- Children with autism show differences in the gut DNA virome compared to non-autistic children: a case control study.BMC pediatrics · 2023Article
Corrections and comments
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Authors and funding
23 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trillions of viruses inhabit the gastrointestinal tract. Some of them have been well-studied on their roles in infection and human health, but the majority remains unsurveyed. It has been established that the composition of the gut virome is highly variable based on the changes of diet, physical state, and environmental factors. However, the effect of host genetic factors, for example ethnic origin, on the gut virome is rarely investigated. Here, we characterized and compared the gut virome in a cohort of local Chinese residents and visiting Pakistani individuals, each group containing twenty-four healthy adults and six children. Using metagenomic shotgun sequencing and assembly of fecal samples, a huge number of viral operational taxonomic units (vOTUs) were identified for profiling the DNA and RNA viromes. National background contributed a primary variation to individuals' gut virome. Compared with the Chinese adults, the Pakistan adults showed higher macrodiversity and different compositional and functional structures in their DNA virome and lower diversity and altered composition in their RNA virome. The virome variations of Pakistan children were not only inherited from that of the adults but also tended to share similar characteristics with the Chinese cohort. We also analyzed and compared the bacterial microbiome between two cohorts and further revealed numerous connections between viruses and bacterial host. Statistically, the gut DNA and RNA viromes were covariant to some extent (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.