ArticleClinical kidney journal2021
Cardiac stunning during haemodialysis: the therapeutic effect of intra-dialytic exercise.
Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Meta-analysis of the effects of exercise interventions on dialysis patients with cardiac function disorders.Frontiers in medicine · 2025Pooled it
- A single bout of hybrid intradialytic exercise did not affect left-ventricular function in exercise-naïve dialysis patients: a randomized, cross-over trial.International urology and nephrology · 2022Trial
- The hemodynamic cost of intermittent hemodialysis and systemic organ stunning.Renal failure · 2026Review
- Dialysis-associated cardiovascular disease risk in children: mechanism and management.Pediatric nephrology (Berlin, Germany) · 2026Review
- Patterns of Hemodialysis-Induced Acute Global Longitudinal Strain Deterioration and Their Predictors.Journal of clinical medicine · 2026Article
- Physical Activity and Exercise for Cardiometabolic Health and Fitness in CKD: An Overview by Exercise Type.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Randomized Controlled Trial of Intradialytic Cycling as Kidney Exercise Rehabilitation for Cardiac Stunning in Hemodialysis (TICKERS_HD): A Clinical Research Protocol.Canadian journal of kidney health and disease · 2026Article
- Assessment and management of emergencies during haemodialysis.Journal of nephrology · 2025Review
- Effect of intradialytic exercise training on hemodialysis-induced myocardial stunning: a pilot-controlled trial.Clinical kidney journal · 2025Article
- Impact of physical activity on surrogate markers of cardiovascular disease in the haemodialysis population.Clinical kidney journal · 2024Article
- A Current State of the Art and Science of Exercise in Dialysis: A Narrative Review.Canadian journal of kidney health and disease · 2024Review
- Diastolic function in chronic kidney disease.Clinical kidney journal · 2023Review
- Exercise and chronic kidney disease: potential mechanisms underlying the physiological benefits.Nature reviews. Nephrology · 2023Review
- Nine Months of Hybrid Intradialytic Exercise Training Improves Ejection Fraction and Cardiac Autonomic Nervous System Activity.Sports (Basel, Switzerland) · 2023Article
- Hypoxia during maintenance hemodialysis-the critical role of pH.Clinical kidney journal · 2023Article
- Evaluation of the impact of an intradialytic exercise programme on sarcopaenia in very elderly haemodialysis patients.Clinical kidney journal · 2022Article
- Clinical practice guideline exercise and lifestyle in chronic kidney disease.BMC nephrology · 2022Article
- Spinning the legs and blood: should intradialytic exercise be routinely offered during maintenance haemodialysis?Clinical kidney journal · 2021Article
- Advances in exercise therapy in predialysis chronic kidney disease, hemodialysis, peritoneal dialysis, and kidney transplantation.Current opinion in nephrology and hypertension · 2020Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular risk is elevated in end-stage renal disease. Left ventricular (LV) dysfunction is linked to repetitive transient ischaemia occurring during haemodialysis (HD). Cardiomyocyte ischaemia results in 'cardiac stunning', evidenced by regional wall motion abnormalities (RWMAs). Ischaemic RWMA have been documented during HD resulting in maladaptive cardiac remodelling and increased risk of heart failure. Intra-dialytic exercise is well tolerated and can improve quality of life and functional capacity. It may also attenuate HD-induced cardiac stunning.
methodsThis exploratory study aimed to assess the effect of intra-dialytic cycle ergometry on cardiac stunning. Twenty exercise-naïve participants on maintenance HD (mean ± SD, 59 ± 11 years) underwent resting echocardiography and maximal cardiopulmonary exercise testing. Subsequently, cardiac stunning was assessed with myocardial strain-derived RWMAs at four time points during (i) standard HD and (ii) HD with 30 min of sub-maximal intra-dialytic cycle ergometry at a workload equivalent to 90% oxygen uptake at the anaerobic threshold (VO
resultsCompared with HD alone, HD with intra-dialytic exercise significantly reduced RWMAs after 2.5 h of HD (total 110 ± 4, mean 7 ± 4 segments versus total 77 ± 3, mean 5 ± 3, respectively; P = 0.008). Global cardiac function, intra-dialytic haemodynamics and LV volumetric parameters were not significantly altered with exercise.
conclusionsIntra-dialytic exercise reduced cardiac stunning. Thirty minutes of sub-maximal exercise at 90% VO
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