Evidence map›Paper›PMID 33959126›Full record

Trial reportFrontiers in immunology2021

T Cell Response Toward Tissue-and Epidermal-Transglutaminases in Coeliac Disease Patients Developing Dermatitis Herpetiformis.

Marzia Caproni, Manuela Capone, Maria Caterina Rossi, Veronica Santarlasci, Laura Maggi, Alessio Mazzoni, Beatrice Rossettini, Daniela Renzi, Lavinia Quintarelli, Beatrice Bianchi and 6 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Marzia CaproniRare Diseases Unit, Section of Dermatology, Department of Health Sciences, USL Toscana Centro, University of Florence, European Reference Network-Skin Member, Florence, Italy.
Manuela CaponeDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Maria Caterina RossiDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Veronica SantarlasciDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Laura MaggiDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Alessio MazzoniDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Beatrice RossettiniDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Daniela RenziDepartment of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Lavinia QuintarelliRare Diseases Unit, Section of Dermatology, Department of Health Sciences, USL Toscana Centro, University of Florence, European Reference Network-Skin Member, Florence, Italy.
Beatrice BianchiDepartment of Health Sciences, University of Florence, Florence, Italy.
Alessandra NinciMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, Florence, Italy.
Gabriele LamiDepartment of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Antonio CalabròDepartment of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Lorenzo CosmiDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Francesco AnnunziatoDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
Francesco LiottaDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.
University of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reason why only few coeliac patients develop the cutaneous manifestation of the disease, named dermatitis herpetiformis (DH), is still unknown. Epidermal transglutaminase (TG3) has been described as the main autoantigen of humoral immunity in DH but the mechanisms leading to this autoimmune response remain obscure. Here we characterized T cells from skin, gut and peripheral blood of DH and coeliac disease (CD) patients, evaluated the impact of the gluten-free diet on circulating T lymphocytes' phenotype and investigated antigen specific T cell response toward epidermal and tissue transglutaminase (TG2). DH patients showed an increased frequency of skin-derived T cells producing TNFα when compared to CD patients. Moreover, circulating T cells producing TNFα and IL-17A positively correlated with clinical score of skin disease activity and decreased after gluten-free diet. Finally, TG2 and TG3-specific T cells resulted more reactive to antigens stimulation in DH patients and showed cross reactivity toward the two autoantigens in both the group of patients. Our data suggest a role of TNFα and IL-17A producing cells in the development of DH and, for the first time, show the existence of a crossed T cell response toward the two transglutaminases isoforms, thus suggesting new insights on T cells role in skin damage.

Indexed as

AdolescentAdultAgedCeliac DiseaseChildDermatitis HerpetiformisFemaleGTP-Binding ProteinsHumansInterleukin-17MaleMiddle AgedProtein Glutamine gamma Glutamyltransferase 2T-LymphocytesTransglutaminasesTumor Necrosis Factor-alphaGTP-Binding ProteinsIL17A protein, humanInterleukin-17Protein Glutamine gamma Glutamyltransferase 2TGM3 protein, humanTransglutaminasesTumor Necrosis Factor-alphaceliac diseasecross reactivityepidermal transglutaminasetissue transglutaminase (TG2)T lymphocytes (CD4+)

Identifiers

PMID33959126
PMCPMC8093623
OpenAlexW3156757392

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.