Evidence map›Paper›PMID 33959101›Full record

ReviewFrontiers in endocrinology2021

Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine.

Alberto Posabella, Andrea B Alber, Hendrik J Undeutsch, Raoul A Droeser, Anthony N Hollenberg, Laertis Ikonomou, Darrell N Kotton

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Alberto PosabellaCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, United States.
Andrea B AlberCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, United States.
Hendrik J UndeutschDivision of Endocrinology, Diabetes and Metabolism, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Raoul A DroeserUniversity Center of Gastrointestinal and Liver Diseases-Clarunis, University of Basel, Basel, Switzerland.
Anthony N HollenbergDivision of Endocrinology, Diabetes and Metabolism, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Laertis IkonomouCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, United States.
Darrell N KottonCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, United States.
Boston Medical Center · USBoston University · USCornell University · USUniversity of Basel · CHWeill Cornell Medicine · US

Funding

A National iPS Cell Network with Deep Phenotyping for Translational ResearchU01TR001810 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GILAD, YOAV, KOTTON, DARRELL N. · 2016 to 2020
$4.4M
Thyroid Follicular Cell Signaling and Development in HumansR01DK105029 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANTHONY N HOLLENBERG, Darrell N. Kotton · 2016 to 2026
$3.7M
NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICAL75N92020C00005 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI N/A, N/A · 2021 to 2024
$2.6M
Biomechanical determinants of lung cell fate in pluripotent stem cellsR01HL124280 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI IKONOMOU, LAERTIS, WONG, JOYCE Y · 2014 to 2017
$1.6M
NCATS NIH HHS U01 TR001810NHLBI NIH HHS 75N92020C00005NHLBI NIH HHS R01 HL124280NIDDK NIH HHS R01 DK105029
6 · The paper itself

Abstract

Stem cell-based therapies to reconstitute

Indexed as

Cell DifferentiationRegenerative MedicineStem Cell TransplantationAnimalsHumansPluripotent Stem CellsThyroid DiseasesThyroid Epithelial Cellscongenital hypothyroidismdirected differentiationpluripotent stem cellsregenerative medicinethyroid follicular cells

Identifiers

PMID33959101
PMCPMC8095374
OpenAlexW3153317755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.