Evidence map›Paper›PMID 33959013›Full record

ArticleFrontiers in pharmacology2021

Berberine-Loaded Carboxylmethyl Chitosan Nanoparticles Ameliorate DSS-Induced Colitis and Remodel Gut Microbiota in Mice.

Luqing Zhao, Xueying Du, Jiaxin Tian, Xiuhong Kang, Yuxin Li, Wenlin Dai, Danyan Li, Shengsheng Zhang, Chao Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Review
  8. Review
  9. Article
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  11. Review
  12. Review
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  15. Review
  16. Article
  17. Intestinal Microecology of Mice Exposed to TiOFoods (Basel, Switzerland) · 2022
    Article
  18. Interactions between Nanoparticles and Intestine.International journal of molecular sciences · 2022
    Review
  19. Review
  20. Current Advances inFrontiers in pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Luqing ZhaoDigestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Xueying DuState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.
Jiaxin TianState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.
Xiuhong KangDigestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Yuxin LiDigestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Wenlin DaiCenter for Applied Statistics, Institute of Statistics and Big Data, Renmin University of China, Beijing, China.
Danyan LiDigestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Shengsheng ZhangDigestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Chao LiState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.
Beijing Hospital of Traditional Chinese Medicine · CNBeijing University of Chemical Technology · CNCapital Medical University · CNRenmin University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a refractory disorder characterized by chronic and recurrent inflammation. The progression and pathogenesis of IBD is closely related to oxidative stress and irregularly high concentrations of reactive oxygen species (ROS). A new oxidation-responsive nano prodrug was constructed from a phenylboronic esters-modified carboxylmethyl chitosan (OC-B) conjugated with berberine (BBR) that degrades selectively in response to ROS. The optimized micelles exhibited well-controlled physiochemical properties and stability in a physiological environment. OC-B-BBR micelles could effectively encapsulate the anti-inflammatory drug berberine and exhibit ideal H

Indexed as

berberinecolitisdrug deliverygut microbiotananoparticles

Identifiers

PMID33959013
PMCPMC8093821
OpenAlexW3152563077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.