Evidence map›Paper›PMID 33959009›Full record

ReviewFrontiers in pharmacology2021

Potential Application of Plant-Based Functional Foods in the Development of Immune Boosters.

Linlin Jiang, Guoqing Zhang, Ye Li, Guirong Shi, Minhui Li

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Synergistic Effects of Carrot (Food science & nutrition · 2025
    Review
  6. Article
  7. Prunin: An Emerging Anticancer Flavonoid.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Plant-Based Diet and Risk of Frailty in Older Chinese Adults.The journal of nutrition, health & aging · 2023
    Article
  13. Article
  14. Understanding immune-modulatory efficacy in vitro.Chemico-biological interactions · 2022
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Linlin JiangDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot, China.
Guoqing ZhangInner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, China.
Ye LiInner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, China.
Guirong ShiBaotou Centre Hospital, Baotou, China.
Minhui LiDepartment of Pharmacy, Inner Mongolia Medical University, Hohhot, China.
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine · CNBaotou Central Hospital · CNInner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune dysfunction, which is responsible for the development of human diseases including cancer, is caused by a variety of factors. Therefore, regulation of the factors influencing the immune response is a potentially effective strategy to counter diseases. Presently, several immune adjuvants are used in clinical practice to enhance the immune response and host defense ability; however, synthetic drugs can exert negative side effects. Thus, the search for natural products of plant origin as new leads for the development of potent and safe immune boosters is gaining considerable research interest. Plant-based functional foods have been shown to exert several immunomodulatory effects in humans; therefore, the application of new agents to enhance immunological and specific host defenses is a promising approach. In this comprehensive review, we have provided an up-to-date report on the use as well as the known and potential mechanisms of bioactive compounds obtained from plant-based functional foods as natural immune boosters. Plant-based bioactive compounds promote immunity through multiple mechanisms, including influencing the immune organs, cellular immunity, humoral immunity, nonspecific immunity, and immune-related signal transduction pathways. Enhancement of the immune response in a natural manner represents an excellent prospect for disease prevention and treatment and is worthy of further research and development using approaches of modern science and technology.

Indexed as

bioactive compounddisease treatmentimmune boosterimmune systemplant-based functional food

Identifiers

PMID33959009
PMCPMC8096308
OpenAlexW3152634576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.