Evidence map›Paper›PMID 33959005›Full record

ArticleFrontiers in pharmacology2021

8-Substituted Triazolobenzodiazepines:

Lalit K Golani, Donna M Platt, Daniela Rüedi-Bettschen, Chitra Edwanker, Shenming Huang, Michael M Poe, Roman Furtmüller, Werner Sieghart, James M Cook, James K Rowlett

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lalit K GolaniDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, United States.
Donna M PlattDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, United States.
Daniela Rüedi-BettschenDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, United States.
Chitra EdwankerDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, United States.
Shenming HuangDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, United States.
Michael M PoeDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, United States.
Roman FurtmüllerBrain Research Institute, Medical University, Vienna, Austria.
Werner SieghartBrain Research Institute, Medical University, Vienna, Austria.
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, United States.
James K RowlettDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, United States.
University of Wisconsin–Milwaukee · USUniversity of Mississippi Medical Center · US

Funding

ANXIOLYTIC EFFECTS AND ABUSE OF BZ RECEPTOR LIGANDSR01DA011792 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROWLETT, JAMES K · 1998 to 2024
$7.8M
Tolerance and Physical Dependence after Chronic Benzodiazepine TreatmentR01DA043204 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI JAMES K ROWLETT · 2017 to 2026
$4.3M
GABA-A receptor subtype mechanisms and the abuse-related effects of alcoholR01AA029023 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2020 to 2024
$2.4M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
EEG Telemetry in Monkeys: Potential Markers of Benzodiazepine ActionR21DA046778 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROWLETT, JAMES K · 2019 to 2020
$426k
NIAAA NIH HHS R01 AA029023NIDA NIH HHS R01 DA011792NIDA NIH HHS R01 DA043204NIDA NIH HHS R21 DA046778NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABA

Indexed as

anxiolyticbenzodiazepinerhesus monkeysedationsquirrel monkey

Identifiers

PMID33959005
PMCPMC8094182
OpenAlexW3154446642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.