Evidence map›Paper›PMID 33959004›Full record

ArticleFrontiers in pharmacology2021

Blood Pressure Changes Following Antihypertensive Medication Reduction, by Drug Class and Dose Chosen for Withdrawal: Exploratory Analysis of Data From the OPTiMISE Trial.

James P Sheppard, Mark Lown, Jenni Burt, Gary A Ford, F D Richard Hobbs, Paul Little, Jonathan Mant, Rupert A Payne, Richard J McManus, OPTiMISE Investigators

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06508619 (Blood Pressure Treatment by the Corsano CardioWatch 287-2 Evaluation Study), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06508619 nacompletednot on this mapstarted 2024, after this paper: background citation

Blood Pressure Treatment by the Corsano CardioWatch 287-2 Evaluation Study

TypeinterventionalSponsorCorsano Health B.V.Ran2024 to 2026Enrolled80ConditionsHigh Blood PressureArmsCorsano CardioWatch 287-2 non-invasive blood pressure (NIBP) monitoring
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Withdrawal of antihypertensive drugs in older people.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

James P SheppardNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Mark LownPrimary Care Research Group, University of Southampton, Southampton, United Kingdom.
Jenni BurtThe Healthcare Improvement Studies Institute, University of Cambridge, Cambridge, United Kingdom.
Gary A FordRadcliffe Department of Medicine, University of Oxford, and Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
F D Richard HobbsNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Paul LittlePrimary Care Research Group, University of Southampton, Southampton, United Kingdom.
Jonathan MantPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Rupert A PayneCentre for Academic Primary Care, Population Health Sciences, University of Bristol, Bristol, United Kingdom.
Richard J McManusNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
OPTiMISE Investigators
University of Oxford · GBUniversity of Cambridge · GBUniversity of Southampton · GBUniversity of Bristol · GB

Funding

Wellcome Trust 211182/Z/18/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

beta-blockerscalcium channel blockersdefined daily dosedeprescribinghypertensionMulti-morbidityolder adultspolypharmacy

Identifiers

PMID33959004
PMCPMC8093867
OpenAlexW3146118107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.