Evidence map›Paper›PMID 33958734›Full record

ReviewBritish journal of cancer2021

Radiomics and radiogenomics in gliomas: a contemporary update.

Gagandeep Singh, Sunil Manjila, Nicole Sakla, Alan True, Amr H Wardeh, Niha Beig, Anatoliy Vaysberg, John Matthews, Prateek Prasanna, Vadim Spektor

Abstract readReview
In one paragraph

Review in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  13. MRI-based clinical radiomics nomogram for the prognostic prediction of adult diffuse low-grade gliomas.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  14. Review
  15. Article
  16. Observational
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  19. Article
  20. Radiomics and radiogenomics in ovarian cancer: a review with a focus on ultrasound applications.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Review

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gagandeep SinghNeuroradiology Division, Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ, USA. gagan32092@gmail.com.ORCID http://orcid.org/0000-0003-4291-9026
Sunil ManjilaDepartment of Neurosurgery, Ayer Neuroscience Institute, The Hospital of Central Connecticut, New Britain, CT, USA.
Nicole SaklaNeuroradiology Division, Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ, USA.
Alan TrueNeuroradiology Division, Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ, USA.
Amr H WardehNeuroradiology Division, Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ, USA.
Niha BeigDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Anatoliy VaysbergNeuroradiology Division, Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ, USA.
John MatthewsNeuroradiology Division, Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ, USA.
Prateek Prasanna *Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY, USA.
Vadim Spektor *Neuroradiology Division, Department of Radiology, Columbia University Medical Center, New York City, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The natural history and treatment landscape of primary brain tumours are complicated by the varied tumour behaviour of primary or secondary gliomas (high-grade transformation of low-grade lesions), as well as the dilemmas with identification of radiation necrosis, tumour progression, and pseudoprogression on MRI. Radiomics and radiogenomics promise to offer precise diagnosis, predict prognosis, and assess tumour response to modern chemotherapy/immunotherapy and radiation therapy. This is achieved by a triumvirate of morphological, textural, and functional signatures, derived from a high-throughput extraction of quantitative voxel-level MR image metrics. However, the lack of standardisation of acquisition parameters and inconsistent methodology between working groups have made validations unreliable, hence multi-centre studies involving heterogenous study populations are warranted. We elucidate novel radiomic and radiogenomic workflow concepts and state-of-the-art descriptors in sub-visual MR image processing, with relevant literature on applications of such machine learning techniques in glioma management.

Indexed as

Brain NeoplasmsGenomicsGliomaHumansMachine LearningMagnetic Resonance ImagingNeoplasm GradingPrognosisRadiographic Image Interpretation, Computer-Assisted

Identifiers

PMID33958734
PMCPMC8405677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.