Evidence map›Paper›PMID 33958614›Full record

ArticleScientific reports2021

Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice.

Mayakannan Manikandan, Steven Walker, Aditi R Deshmukh, Elizabeth Perea, Danqi Wang, Kumar N Alagramam, Ruben Stepanyan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Role of Calcium Signaling in Sensorineural Hearing Loss.International journal of medical sciences · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Mitochondrial calcium cycling in neuronal function and neurodegeneration.Frontiers in cell and developmental biology · 2023
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mayakannan ManikandanDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.
Steven WalkerDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.
Aditi R DeshmukhDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.
Elizabeth PereaDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.
Danqi WangSwagelok Center for Surface Analysis of Materials, Case Western Reserve University, Cleveland, OH, 44106, USA.
Kumar N AlagramamDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.
Ruben StepanyanDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA. rxs690@case.edu.
University Hospitals of Cleveland · USCase Western Reserve University · US

Funding

Mechanotransduction and calcium regulation in cochlear hair cellsR01DC015016 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI STEPANYAN, RUBEN · 2016 to 2020
$1.7M
NIDCD NIH HHS R01 DC015016
6 · The paper itself

Abstract

Mitochondrial Ca

Indexed as

AnimalsCalciumCalcium ChannelsFemaleHair Cells, AuditoryHearingHomeostasisMaleMiceMice, Inbred CBAMice, KnockoutMitochondriaMitochondrial ProteinsCalciumCalcium ChannelsMcu protein, mouseMitochondrial Proteins

Identifiers

PMID33958614
PMCPMC8102556
OpenAlexW3159640748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.