Trial reportOpen heart2021
Patient delay and benefit of timely reperfusion in ST-segment elevation myocardial infarction.
Trial report in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00794001 (Feedback Intervention and Treatment Times in ST- Elevation Myocardial Infarction), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feedback Intervention and Treatment Times in ST- Elevation Myocardial Infarction (FITT-STEMI): A Multicenter Trial Analyzing the Effects of Systematic Data Feedback on Treatment Quality and Survival Rates.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Types and effects of feedback for emergency ambulance staff: a systematic mixed studies review and meta-analysis.BMJ quality & safety · 2023Pooled it
- Temporal trends and prognostic impact of pre-hospital delay in ST-elevation myocardial infarction-20-year observational study from the SWEDEHEART registry.European heart journal. Acute cardiovascular care · 2026Observational
- Temporal improvements in prehospital systems-of-care for ST-elevation myocardial infarction patients in Victoria, Australia: a retrospective study.BMC emergency medicine · 2026Article
- The quality of care and long-term mortality of patients with ST-elevation myocardial infarction and cardiac devices: a nationwide cohort study.European heart journal open · 2025Article
- Occupational status and outcomes in acute myocardial infarction: a prospective cohort study.BMC public health · 2025Article
- Netherlands Heart Registration-based multicentre retrospective cohort study on primary PCI for ST-elevation myocardial infarction: comparing patient relevant outcomes in on- vs. off-hour presentations.European heart journal open · 2025Article
- Reevaluating STEMI: The Utility of the Occlusive Myocardial Infarction Classification to Enhance Management of Acute Coronary Syndromes.Current cardiology reports · 2025Review
- Article
- Delays in first medical contact to primary interventional therapy and left ventricular remodelling in ST-segment elevation myocardial infarction.Irish journal of medical science · 2023Article
- Delays in first medical contact to primary interventional therapy and left ventricular remodelling in ST-segment elevation myocardial infarction.Irish journal of medical science · 2023Article
- Exercise training and experimental myocardial ischemia and reperfusion: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2023Review
- The presentation delay and differences of symptoms manifestation in Myocardial Infarction patients with and without Diabetes: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Metallothionein-2A Protects Cardiomyocytes from Hypoxia/reper-Fusion through Inhibiting p38.Cell biochemistry and biophysics · 2023Article
- Comparing Door-To-Balloon Time between ST-Elevation Myocardial Infarction Electrocardiogram and Its Equivalents.Journal of clinical medicine · 2022Article
- If "Time Is Muscle," Then the Patient's Knowledge Must Save Time.Arquivos brasileiros de cardiologia · 2022Article
- Public attention to cardiac arrest in China: A Baidu Index analysis of online search trends and hotspot events.Digital healthArticle
- Predicting Reduced Left Ventricular Ejection Fraction in Patients With ST-Elevation Myocardial Infarction: Role of the Quick Forrester Classification.Acute medicine & surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with ST-segment elevation myocardial infarction (STEMI), it is unknown how patient delay modulates the beneficial effects of timely reperfusion.
aimsTo assess the prognostic significance of a contact-to-balloon time of less than 90 min on in-hospital mortality in different categories of symptom-onset-to-first-medical-contact (S2C) times.
methodsA total of 20 005 consecutive patients from the Feedback Intervention and Treatment Times in ST-segment Elevation Myocardial Infarction (FITT-STEMI) programme treated with primary percutaneous coronary intervention (PCI) were included.
resultsThere were 1554 deaths (7.8%) with a J-shaped relationship between mortality and S2C time. Mortality was 10.0% in patients presenting within 1 hour, and 4.9%, 6.0% and 7.3% in patient groups with longer S2C intervals of 1-2 hours, 2-6 hours and 6-24 hours, respectively. Patients with a short S2C interval of less than 1 hour (S2C<60 min) had the highest survival benefit from timely reperfusion with PCI within 90 min (OR 0.27, 95% CI 0.23 to 0.31, p<0.0001) as compared with the three groups with longer S2C intervals of 1 hour<S2C≤2 hours (OR 0.44, 95% CI 0.33 to 0.59, p<0.0001), 2 hours<S2C≤6 hours (OR 0.49, 95% CI 0.38 to 0.64, p<0.0001) and 6 hours<S2C≤24 hours (OR 0.42, 95% CI 0.30 to 0.58, p<0.0001).
conclusionsTimely reperfusion with a contact-to-balloon time of less than 90 min is most effective in patients presenting with short S2C intervals of less than 1 hour, but has also beneficial effects in patients with S2C intervals of up to 24 hours. TRIAL REGISTRATION NUMBER: NCT00794001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.