ArticleMolecular pharmacology2021
Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate
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Article in Molecular pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- The relationship between apparent potentiation and the magnitude of the control response.The Journal of general physiology · 2026Article
- Persistent impact of in utero nanoparticle exposure on metabolic and endocrine outcomes in adult rats fed a high-fat diet.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- Glabridin Hypnosis in Zebrafish Larvae Is Associated With Effects on Multiple Anesthetic Target Receptors.Anesthesia and analgesia · 2025Article
- Interaction Between Allopregnanolone and Amiloride Binding Sites on the GABACell biochemistry and biophysics · 2025Article
- A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity.Science advances · 2025Article
- Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABARSC advances · 2024Article
- Direct measurements of neurosteroid binding to specific sites on GABABritish journal of pharmacology · 2024Article
- Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor.Molecular pharmacology · 2024Article
- Neurosteroids and their potential as a safer class of general anesthetics.Journal of anesthesia · 2024Review
- Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay.ACS chemical neuroscience · 2024Article
- Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABABiomolecules · 2023Article
- The Mechanism of Enantioselective Neurosteroid Actions on GABABiomolecules · 2023Article
- Modulation of the mammalian GABABritish journal of pharmacology · 2022Article
- Activation of the Rat α1β2ε GABABiomolecules · 2022Article
- (+)-Catharanthine potentiates the GABABiochemical pharmacology · 2022Article
- Neurosteroid Modulation of GABACurrent neuropharmacology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Allison L GermannDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.).
Spencer R PierceDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.).
Hiroki TateiwaDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.).
Yusuke SugasawaDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.).
David E ReichertDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.).
Alex S EversDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.).
Joe Henry SteinbachDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.).
Gustav AkkDepartments of Anesthesiology (A.L.G., S.R.P., H.T., A.S.E., J.H.S., G.A.) and Radiology (D.E.R.), and the Taylor Family Institute for Innovative Psychiatric Research (D.E.R., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri; and Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan (Y.S.) akk@morpheus.wustl.edu.
Taylor Family Institute for Innovative Psychiatric ResearchJuntendo University · JP
Funding
MOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0MSYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4MNIGMS NIH HHS R01 GM108580NIGMS NIH HHS R01 GM108799
Abstract
Prior work employing functional analysis, photolabeling, and X-ray crystallography have identified three distinct binding sites for potentiating steroids in the heteromeric GABA
Indexed as
Amino Acid SubstitutionAnimalsBinding SitesCrystallography, X-RayModels, MolecularMolecular ConformationMolecular Docking SimulationMultiprotein ComplexesPregnanoloneRatsReceptors, GABA-AGabra1 protein, ratGabrb2 protein, ratGabrg2 protein, ratMultiprotein ComplexesPregnanoloneReceptors, GABA-A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.