SynthesisThe European respiratory journal2021
Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study.
Synthesis in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Causal effects from tobacco smoking initiation on obesity-related traits: a Mendelian randomization study.International journal of obesity (2005) · 2023Pooled it
- Causal Effect of Kidney Function on Lipid Metabolism: An Integrated Population-Scale Observational Analysis and Mendelian Randomization Study.Kidney medicine · 2026Article
- Pulmo-Cardio-Renal Continuum in Chronic Lung Diseases: A 3-Year Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Immunological phenotype in asthma and its impact on long-term renal outcomes.Scientific reports · 2025Article
- PM2.5 increases the risk of early-onset COPD mediated by smoking and shared genes: a large-scale genetic analysis.Clinical and experimental medicine · 2025Article
- Preserved ratio impaired spirometry, airflow obstruction, and their trajectories in relationship to chronic kidney disease: a prospective cohort study.Scientific reports · 2025Article
- Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank.BMC medicine · 2024Article
- Relationship between diabetes-related clinical characteristics and preserved ratio impaired spirometry (PRISm): findings from NHANES 2007-2012.BMJ public health · 2024Article
- Validation of an interactive process mining methodology for clinical epidemiology through a cohort study on chronic kidney disease progression.Scientific reports · 2024Article
- Kidney Function Measures and Mortality: A Mendelian Randomization Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants.BMC medicine · 2024Article
- Unraveling the causality between chronic obstructive pulmonary disease and its common comorbidities using bidirectional Mendelian randomization.European journal of medical research · 2024Article
- Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study.Kidney research and clinical practice · 2023Article
- Genetically Predicted Body Selenium Concentration and estimated GFR: A Mendelian Randomization Study.Kidney international reports · 2023Article
- Intestinal homeostasis in the gut-lung-kidney axis: a prospective therapeutic target in immune-related chronic kidney diseases.Frontiers in immunology · 2023Review
- Kidney function and cardiovascular diseases: a large-scale observational and Mendelian randomization study.Frontiers in immunology · 2023Article
- Serum bilirubin and kidney function: a Mendelian randomization study.Clinical kidney journal · 2022Article
- Mendelian randomization reveals causal effects of kidney function on various biochemical parameters.Communications biology · 2022Article
- Nonlinear causal effects of estimated glomerular filtration rate on myocardial infarction risks: Mendelian randomization study.BMC medicine · 2022Article
- Distinguishing causation from genetic correlation in a Mendelian randomisation framework.The European respiratory journal · 2021Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdditional study is warranted to investigate the causal effects between kidney function and obstructive lung disease.
methodsThis study was a bidirectional two-sample Mendelian randomisation (MR) analysis. The Chronic Kidney Disease Genetics (CKDGen) genome-wide association study (GWAS) meta-analysis for estimated glomerular filtration rate (eGFR) including individuals of European ancestry (n=567 460) provided the genetic instrument for kidney function and outcome summary statistics. A GWAS for forced expiratory volume in 1 s (FEV
resultsThe causal estimates by summary-level MR indicated that genetically predicted increased kidney function was significantly associated with increased FEV
conclusionThis study supports kidney function impairment as a causative factor for obstructive lung disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.