ArticleAJNR. American journal of neuroradiology2021
Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Mapping white matter microstructure at term age to motor outcomes at 2 years in very preterm infants: a multicentre cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Prenatal Adversity and Neonatal White Matter Microstructure Independently Relate to Language Outcomes at Age 2 Years.The Journal of pediatrics · 2025Article
- An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study.Journal of neurology · 2024Article
- Corpus Callosum Abnormalities at Term-Equivalent Age Are Associated with Language Development at 2 Years' Corrected Age in Infants Born Very Preterm.Journal of pediatrics. Clinical practice · 2024Article
- Structural connectivity at term equivalent age and language in preterm children at 2 years corrected.Brain communications · 2024Article
- Corpus callosum abnormalities at term-equivalent age are associated with language development at two years corrected age in infants born very preterm.medRxiv : the preprint server for health sciences · 2023Article
- A Semi-Supervised Graph Convolutional Network for Early Prediction of Motor Abnormalities in Very Preterm Infants.Diagnostics (Basel, Switzerland) · 2023Article
- Bio-psycho-social factors' associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants.Frontiers in psychology · 2023Article
- Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies.Human brain mapping · 2022Article
- Expert consensus on the clinical practice of neonatal brain magnetic resonance imaging.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Early structural connectivity within the sensorimotor network: Deviations related to prematurity and association to neurodevelopmental outcome.Frontiers in neuroscience · 2022Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
background and purposeMicrostructural white matter abnormalities on DTI using Tract-Based Spatial Statistics at term-equivalent age are associated with cognitive and motor outcomes at 2 years of age or younger. However, neurodevelopmental tests administered at such early time points are insufficiently predictive of mild-moderate motor and cognitive impairment at school age. Our objective was to evaluate the microstructural antecedents of cognitive and motor outcomes at 3 years' corrected age in a cohort of very preterm infants. MATERIALS AND
methodsWe prospectively recruited 101 very preterm infants (<32 weeks' gestational age) and performed DTI at term-equivalent age. The Differential Ability Scales, 2nd ed, Verbal and Nonverbal subtests, and the Bayley Scales of Infant and Toddler Development, 3rd ed, Motor subtest, were administered at 3 years of age. We correlated DTI metrics from Tract-Based Spatial Statistics with the
resultsOf the 101 subjects, 84 had high-quality DTI data, and of these, 69 returned for developmental testing (82%). Their mean (SD) gestational age was 28.4 (2.5) weeks, and birth weight was 1121.4 (394.1) g. DTI metrics were significantly associated with Nonverbal Ability in the corpus callosum, posterior thalamic radiations, fornix, and inferior longitudinal fasciculus and with Motor scores in the corpus callosum, internal and external capsules, posterior thalamic radiations, superior and inferior longitudinal fasciculi, cerebral peduncles, and corticospinal tracts.
conclusionsWe identified widespread microstructural white matter abnormalities in very preterm infants at term that were significantly associated with cognitive and motor development at 3 years' corrected age.
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