Evidence map›Paper›PMID 33958329›Full record

ArticleAJNR. American journal of neuroradiology2021

The Fetus with Ganglionic Eminence Abnormality: Head Size and Extracranial Sonographic Findings Predict Genetic Diagnoses and Postnatal Outcomes.

S K Goergen, E Alibrahim, J Christie, A Dobrotwir, M Fahey, L Fender, K Frawley, S A Manikkam, J R Pinner, S Sinnott and 5 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  8. TUBB3 and KIF21A in neurodevelopment and disease.Frontiers in neuroscience · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 2 countries.

S K GoergenFrom the Monash Imaging (S.K.G.), Monash Health, Victoria, Australia stacy.goergen@monashhealth.org.ORCID 0000-0001-9668-6809
E AlibrahimDepartment of Radiology (E.A., A.D.), Royal Women's Hospital, Parkville, Victoria, Australia.ORCID 0000-0002-8366-0834
J ChristiePRP Imaging (J.C.), Sydney, New South Wales, Australia.ORCID 0000-0002-3917-0360
A DobrotwirDepartment of Radiology (E.A., A.D.), Royal Women's Hospital, Parkville, Victoria, Australia.ORCID 0000-0003-3420-6472
M FaheyDepartment of Paediatrics (M.F.), School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.ORCID 0000-0003-0811-4785
L FenderDepartment of Radiology (L.F.), King Edward Memorial Hospital, Perth, Western Australia, Australia.ORCID 0000-0002-4183-025X
K FrawleyDepartment of Medical Imaging and Nuclear Medicine (K.F., S.A.M.), Queensland Children's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-5858-5609
S A ManikkamDepartment of Medical Imaging and Nuclear Medicine (K.F., S.A.M.), Queensland Children's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-0701-5534
J R PinnerCentre for Clinical Genetics (J.R.P.), Sydney Children's Hospital, Sydney, New South Wales, Australia.ORCID 0000-0002-8323-1802
S SinnottSO + GI Scan I-MED Radiology (S.S.), Department of Medical Imaging, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-3028-6631
R RomanielloChild Neuropsychiatry and Neurorehabilitation Department (R.R.), Scientific Institute Eugenio Medea, La Nostra Famiglia, Bosiso Parini, Lecco, Italy.ORCID 0000-0002-8709-6732
S A SandaraduraDiscipline of Child and Adolescent Health (S.A.S.), Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia.ORCID 0000-0003-1393-8148
J TaylorDepartment of Radiology (J.T.), Prince of Wales Hospital, Sydney, New South Wales, Australia.ORCID 0000-0001-8492-9092
A VasudevanDepartment of Clinical Genetics (A.V.), Royal Women's Hospital, Parkville, Victoria, Australia.ORCID 0000-0002-9520-8845
A RighiniDepartment of Pediatric Radiology and Neuroradiology (A.R.), Vittore Buzzi Children's Hospital, Milan, Italy.ORCID 0000-0003-3396-7413
Royal Women's Hospital · AUChildren's Health Queensland Hospital and Health Service · AUMonash Health · AUIRCCS Eugenio Medea · ITKing Edward Memorial Hospital · AUOlympus (Australia) · AUOspedale dei Bambini Vittore Buzzi · ITPrince of Wales Hospital · AURoyal Brisbane and Women's Hospital · AUThe University of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeGanglionic eminence abnormalities on fetal MR imaging are associated with cerebral malformations. Their presumed genetic basis and associated postnatal outcomes remain largely unknown. We aimed to elucidate these through a multicenter study. MATERIALS AND

methodsBetween January 2010 and June 2020, seven hospitals in 2 countries performing fetal MR imaging examinations identified fetal MR imaging studies demonstrating ganglionic eminence enlargement, cavitation, or both. Cases with no genetic diagnosis, no whole exome sequencing, or no outcome of a liveborn child were excluded. Head size was classified as large (fronto-occipital diameter > 95th centile), small (fronto-occipital diameter <5th centile), or normal.

resultsTwenty-two fetuses with ganglionic eminence abnormalities were identified. Of 8 with large heads, 2 were diagnosed with

conclusionsFetal head size and extracranial prenatal sonographic findings can refine the phenotype and facilitate genetic diagnosis when ganglionic eminence abnormality is diagnosed with MR imaging.

Indexed as

HydrocephalusMegalencephalyPolydactylyPolymicrogyriaFemaleFetusHumansPregnancy

Identifiers

PMID33958329
PMCPMC8367629
OpenAlexW3159339175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.