Evidence map›Paper›PMID 33958278›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2021

Rapid cystic fibrosis lung-function decline and in-vitro CFTR modulation.

Emrah Gecili, Weiji Su, Cole Brokamp, Eleni-Rosalina Andrinopoulou, Francis J LaRosa, Teresa Pestian, John P Clancy, George M Solomon, John J Brewington, Rhonda D Szczesniak

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Toward in vivo bronchoscopic functional CFTR assessment using a short circuit current measurement probe.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emrah GeciliDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Weiji SuLilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Cole BrokampDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, MLC 0555, 3230 Eden Ave, Cincinnati, OH 45267, USA.
Eleni-Rosalina AndrinopoulouDepartment of Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, the Netherlands.
Francis J LaRosaDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, MLC 2021, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Teresa PestianDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
John P ClancyCystic Fibrosis Foundation, 4550 Montgomery Ave, Suite 1100N, Bethesda, MD 20814, USA.
George M SolomonGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, MCLM 706, 1918 University Blvd, Birmingham, AL 35294, USA; Department of Medicine, University of Alabama at Birmingham, THT 422, 1900 University Blvd, Birmingham, AL 35294, USA.
John J BrewingtonDepartment of Pediatrics, University of Cincinnati, MLC 0555, 3230 Eden Ave, Cincinnati, OH 45267, USA; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, MLC 2021, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Rhonda D SzczesniakDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, MLC 0555, 3230 Eden Ave, Cincinnati, OH 45267, USA; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, MLC 2021, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
R01- Mapping environmental contributions to rapid lung disease progression in cystic fibrosisR01HL141286 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SZCZESNIAK, RHONDA · 2019 to 2023
$2.3M
Personalized Model Systems to Predict and Investigate CFTR Drug Response in CFK08HL144825 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BREWINGTON, JOHN JOSEPH · 2019 to 2023
$818k
NHLBI NIH HHS K08 HL144825NHLBI NIH HHS R01 HL141286NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentBiomarkersChildChloride Channel AgonistsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDisease ProgressionFemaleHumansMalePilot ProjectsPrincipal Component AnalysisRespiratory Function TestsYoung AdultBiomarkersChloride Channel AgonistsCystic Fibrosis Transmembrane Conductance Regulator

Identifiers

PMID33958278
PMCPMC8803536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.