Evidence map›Paper›PMID 33958265›Full record

ReviewThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021

Innate allorecognition in transplantation.

Khodor I Abou-Daya, Martin H Oberbarnscheidt

Abstract readReview
In one paragraph

Review in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
  6. Review
  7. Article
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  10. Article
  11. Review
  12. Review
  13. Failing Heart Transplants and Rejection-A Cellular Perspective.Journal of cardiovascular development and disease · 2021
    Review
  14. Innate Immune Memory in Macrophages.Newborn (Clarksville, Md.)
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Khodor I Abou-DayaThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Martin H OberbarnscheidtThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: mho6@pitt.edu.

Funding

Tertiary Lymphoid Organs in TransplantationR01AI145881 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OBERBARNSCHEIDT, MARTIN H · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI145881
6 · The paper itself

Abstract

Successful allogeneic transplantation has been made possible by suppressing activation of the adaptive immune system. Current immunosuppressive therapy prevents rejection by targeting T and B cells. Despite this effective treatment, it is the innate immune system, which includes dendritic cells, monocytes, natural killer cells, that is responsible for the initiation of the adaptive immune response. Recent work has described that the innate immune system is capable of recognizing allogeneic nonself and some of the mechanisms of innate allorecognition have been uncovered. Better understanding of the role of the innate immune system in initiation and maintenance of the allo-immune response has potential to lead to better treatment strategies for transplant patients, prolonging allograft survival. Here, we review advances in our understanding of innate allorecognition in transplantation.

Indexed as

Organ TransplantationGraft RejectionHumansImmunity, InnateTransplantation, Homologousallorecognitiondendritic cellinnate immunitymonocytemonocyte memorytransplantation

Identifiers

PMID33958265
PMCPMC8238827

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.