Evidence map›Paper›PMID 33958126›Full record

ArticleJournal of the American College of Cardiology2021

Chronobiology of Natriuretic Peptides and Blood Pressure in Lean and Obese Individuals.

Vibhu Parcha, Nirav Patel, Orlando M Gutierrez, Peng Li, Karen L Gamble, Kiran Musunuru, Kenneth B Margulies, Thomas P Cappola, Thomas J Wang, Garima Arora and 1 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03834168 nacompletednot on this map

The Diurnal Rhythm in Natriuretic Peptide Levels and Relationship With Nocturnal Blood Pressure

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2019 to 2021Enrolled42ConditionsNatriuretic Peptides, Obesity, Nocturnal Blood PressureArmsstandardized Study Diet
NCT04971720 phase2 / phase3recruitingnot on this mapstarted 2022, after this paper: background citation

Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2022 to 2027Enrolled160ConditionsObesity, Cardiovascular Diseases, Hypertension, Nocturnal Blood PressureArmsSacubitril-Valsartan 49 Mg-51 Mg Oral Tablet, Valsartan 80 mg Oral Tablet
NCT05216042 narecruitingnot on this mapstarted 2022, after this paper: background citation

Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2022 to 2027Enrolled200ConditionsCardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy ExpenditureArmsStudy diet, Exercise capacity VO2 max determination, Exercise Challenge, Glucose Challenge
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Angiotensin receptor neprilysin inhibitor for the treatment of hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Vibhu ParchaDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address: https://twitter.com/vibhuparcha.
Nirav PatelDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Orlando M GutierrezDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Peng LiSchool of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Karen L GambleDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kiran MusunuruCardiovascular Institute, Department of Medicine, Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: https://twitter.com/kiranmusunuru.
Kenneth B MarguliesDivision of Cardiovascular Medicine, Department of Medicine, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Thomas P CappolaDivision of Cardiovascular Medicine, Department of Medicine, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Thomas J WangDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: https://twitter.com/thomasjwang1.
Garima AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address: https://twitter.com/GarimaAroraMD.
Pankaj AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA; Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA. Electronic address: parora@uabmc.edu.

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Race, Natriuretic Peptides and Physiological PerturbationsK23HL146887 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ARORA, PANKAJ · 2019 to 2023
$969k
NCATS NIH HHS UL1 TR001417NHLBI NIH HHS K23 HL146887
6 · The paper itself

Abstract

backgroundDiurnal variation of natriuretic peptide (NP) levels and its relationship with 24-h blood pressure (BP) rhythm has not been established. Obese individuals have a relative NP deficiency and disturbed BP rhythmicity.

objectivesThis clinical trial evaluated the diurnal rhythmicity of NPs (B-type natriuretic peptide [BNP], mid-regional pro-atrial natriuretic peptide [MR-proANP], N-terminal pro-B-type natriuretic peptide [NT-proBNP]) and the relationship of NP rhythm with 24-h BP rhythm in healthy lean and obese individuals.

methodsOn the background of a standardized diet, healthy, normotensive, lean (body mass index 18.5 to 25 kg/m

resultsAmong 52 participants screened, 40 participants (18 lean, 22 obese; 50% women; 65% Black) completed the study. The median range spread (percentage difference between the minimum and maximum values) over 24 h for MR-proANP, BNP, and NT-proBNP levels was 72.0% (interquartile range [IQR]: 50.9% to 119.6%), 75.5% (IQR: 50.7% to 106.8%), and 135.0% (IQR: 66.3% to 270.4%), respectively. A cosine wave-shaped 24-h oscillation of normalized NP levels (BNP, MR-proANP, and NT-proBNP) was noted both in lean and obese individuals (p

conclusionsThis human physiological trial elucidates evidence of diurnal NP rhythmicity and the presence of an NP-BP rhythm axis. There exists a misalignment of the NP-BP diurnal rhythm in the obese, which may contribute to the disturbed diurnal BP pattern observed among obese individuals. (The Diurnal Rhythm in Natriuretic Peptide Levels; NCT03834168).

Indexed as

AdolescentAdultBlood PressureChronobiology PhenomenaFemaleHumansMaleNatriuretic PeptidesObesityYoung AdultNatriuretic Peptidesblood pressurediurnal rhythmhypertensionnatriuretic peptidesobesity

Identifiers

PMID33958126
PMCPMC8138944

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.