ArticleGenetics, selection, evolution : GSE2021
Assessment of trade-offs between feed efficiency, growth-related traits, and immune activity in experimental lines of layer chickens.
Article in Genetics, selection, evolution : GSE, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- A review on applying immunological methods in animal research.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Review
- Livestock immunomodulators as alternatives to antimicrobials - a roadmap for the fight against drug resistance.BMC veterinary research · 2026Review
- Strain-specific genetic relationships between Mycoplasma synoviae immunity and egg production traits in two layer lines.Poultry science · 2026Article
- Identification of Association Between Mucus Microbiota and Gene Expression in the Gill of aAnimals : an open access journal from MDPI · 2026Article
- Immunological studies on new rabbit paternal lines with different potentials for growth rate and resilience: pathways towards healthier animals.Veterinary research · 2025Article
- Synergistic effects of zinc oxide and selenium nanoparticles in drinking water on broiler chicken growth, antioxidant, and immunity responses.Veterinary and animal science · 2025Article
- A framework for challenges and solutions in biodesign research.Biodesign research · 2025Article
- Article
- The effects of rosmarinic acid and antibiotics on the intestinal morphology, function, and cecal microbiota of broiler chickens.Journal of animal science · 2025Article
- Sequence variants associated with resilient responses in growing pigs.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages.Frontiers in immunology · 2025Article
- Residual feed intake in late-laying hens: immune function, metabolic efficiency, and feed utilization dynamics.Frontiers in veterinary science · 2025Article
- Selection for Resilience in Livestock Production Systems.International journal of molecular sciences · 2024Review
- Transcriptomic Profiling Reveals Altered Expression of Genes Involved in Metabolic and Immune Processes in NDV-Infected Chicken Embryos.Metabolites · 2024Article
- Hepatic Transcriptomics of Broilers with Low and High Feed Conversion in Response to Caloric Restriction.Metabolites · 2024Article
- Evaluation of selection strategies in dual-purpose and specialized breeding of indigenous chicken.Poultry science · 2024Article
- Relationship between feed efficiency and gut microbiota in laying chickens under contrasting feeding conditions.Scientific reports · 2024Article
- Validation of a phenotyping method to identify porcine reproductive and respiratory syndrome virus-resilient sows and its impact on sow stayability.Journal of animal science · 2024Article
- The future of feed formulation for poultry: Toward more sustainable production of meat and eggs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn all organisms, life-history traits are constrained by trade-offs, which may represent physiological limitations or be related to energy resource management. To detect trade-offs within a population, one promising approach is the use of artificial selection, because intensive selection on one trait can induce unplanned changes in others. In chickens, the breeding industry has achieved remarkable genetic progress in production and feed efficiency over the last 60 years. However, this may have been accomplished at the expense of other important biological functions, such as immunity. In the present study, we used three experimental lines of layer chicken-two that have been divergently selected for feed efficiency and one that has been selected for increased antibody response to inactivated Newcastle disease virus (ND3)-to explore the impact of improved feed efficiency on animals' immunocompetence and, vice versa, the impact of improved antibody response on animals' growth and feed efficiency.
resultsThere were detectable differences between the low (R+) and high (R-) feed-efficiency lines with respect to vaccine-specific antibody responses and counts of monocytes, heterophils, and/or T cell population. The ND3 line presented reduced body weight and feed intake compared to the control line. ND3 chickens also demonstrated an improved antibody response against a set of commercial viral vaccines, but lower blood leucocyte counts.
conclusionsThis study demonstrates the value of using experimental chicken lines that are divergently selected for RFI or for a high antibody production, to investigate the modulation of immune parameters in relation to growth and feed efficiency. Our results provide further evidence that long-term selection for the improvement of one trait may have consequences on other important biological functions. Hence, strategies to ensure optimal trade-offs among competing functions will ultimately be required in multi-trait selection programs in livestock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.